Dissemination of cfr-mediated linezolid resistance among Staphylococcus species isolated from a teaching hospital in Beijing, China
In: Journal of International Medical Research, Jg. 46 (2018-07-01), S. 3884-3889
Online
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Zugriff:
Objective The aim of the present study was to report the dissemination of cfr and fexA genes mediated by linezolid resistance among Staphylococcus species. Methods Three methicillin-resistant staphylococci that were collected from a teaching hospital in Beijing were identified as linezolid-resistant. These three staphylococci were Staphylococcus aureus, S. haemolyticus, and S. cohnii. Mutations in domain V of 23S ribosomal RNA, ribosomal proteins, and the cfr, fexA, and optrA genes were analysed. Results The three isolates had no mutations of 23S ribosomal RNA, but showed mutations in the cfr and fexA genes. Mutations in the gene for ribosomal protein L3, which resulted in the amino acid exchanges Gly108Glu, Ser158Phe, and Asp159Tyr, were identified in S. cohnii X4535. Conclusions This is the first report of the cfr gene in clinical linezolid-resistant methicillin-resistant S. aureus isolated from Beijing. L3 mutations coupled with the cfr and fexA genes may act synergistically. Potential transmissibility of this agent, even without prior exposure to linezolid, may have serious epidemiological repercussions.
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Dissemination of cfr-mediated linezolid resistance among Staphylococcus species isolated from a teaching hospital in Beijing, China
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Autor/in / Beteiligte Person: | Jian, Jiyong ; Zhang, Man ; Chen, Liang ; Xie, Zeqiang |
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Zeitschrift: | Journal of International Medical Research, Jg. 46 (2018-07-01), S. 3884-3889 |
Veröffentlichung: | SAGE Publications, 2018 |
Medientyp: | unknown |
ISSN: | 1473-2300 (print) ; 0300-0605 (print) |
DOI: | 10.1177/0300060518781636 |
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