In vivo electrochemical evidence that the tricyclic antidepressant femoxetine potentiates the morphine-induced increase in 5-HT metabolism in the medullary dorsal horn of freely moving rats
In: Brain Research, Jg. 553 (1991-07-01), S. 222-228
Online
unknown
Zugriff:
Acute administration of tricyclic antidepressants (TCAs) is known to potentiate morphine antinociception. At the medullary dorsal horn (MDH) level systemic morphine has been shown to increase serotonin (5-HT) metabolism as measured by in vivo electrochemistry in freely moving rats. Using similar electrochemical detection of 5-hydroxyindole (peak '3') within the MDH, the present study investigated the effect of the specific 5-HT uptake inhibitor femoxetine on peak 3 and the effects of this TCA on changes in 5-HT metabolism induced by morphine. Acutely administered femoxetine (40 mg/kg i.p.) (i) induced a small but significant increase in peak 3 and (ii) strongly potentiated the effect of morphine (10 mg/kg i.p.) on 5-HT metabolism, this potentiation being opiate specific since simultaneous injection of naloxone (1 mg/kg i.p.) abolished the effect of morphine. These findings provide an in vivo neurochemical basis for the potentiation of morphine antinociception by TCAs. They further emphasize the importance of 5-HT bulbospinal descending pathways in morphine antinociception.
Titel: |
In vivo electrochemical evidence that the tricyclic antidepressant femoxetine potentiates the morphine-induced increase in 5-HT metabolism in the medullary dorsal horn of freely moving rats
|
---|---|
Autor/in / Beteiligte Person: | Rivot, J.P. ; Besson, J.M. ; Puig, S. |
Link: | |
Zeitschrift: | Brain Research, Jg. 553 (1991-07-01), S. 222-228 |
Veröffentlichung: | Elsevier BV, 1991 |
Medientyp: | unknown |
ISSN: | 0006-8993 (print) |
DOI: | 10.1016/0006-8993(91)90829-k |
Schlagwort: |
|
Sonstiges: |
|