Normal Liver Tissue Density Dose Response in Patients Treated With Stereotactic Body Radiation Therapy for Liver Metastases
In: International Journal of Radiation Oncology*Biology*Physics, Jg. 84 (2012-11-01), S. e441- (6S.)
Online
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Zugriff:
Purpose To evaluate the temporal dose response of normal liver tissue for patients with liver metastases treated with stereotactic body radiation therapy (SBRT). Methods and Materials Ninety-nine noncontrast follow-up computed tomography (CT) scans of 34 patients who received SBRT between 2004 and 2011 were retrospectively analyzed at a median of 8 months post-SBRT (range, 0.7-36 months). SBRT-induced normal liver tissue density changes in follow-up CT scans were evaluated at 2, 6, 10, 15, and 27 months. The dose distributions from planning CTs were mapped to follow-up CTs to relate the mean Hounsfield unit change (ΔHU) to dose received over the range 0-55 Gy in 3-5 fractions. An absolute density change of 7 HU was considered a significant radiographic change in normal liver tissue. Results Increasing radiation dose was linearly correlated with lower post-SBRT liver tissue density (slope, −0.65 ΔHU/5 Gy). The threshold for significant change (−7 ΔHU) was observed in the range of 30-35 Gy. This effect did not vary significantly over the time intervals evaluated. Conclusions SBRT induces a dose-dependent and relatively time-independent hypodense radiation reaction within normal liver tissue that is characterized by a decrease of >7 HU in liver density for doses >30-35 Gy.
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Normal Liver Tissue Density Dose Response in Patients Treated With Stereotactic Body Radiation Therapy for Liver Metastases
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Autor/in / Beteiligte Person: | Stinauer, Michelle A. ; Christopher Corey Howells ; Miften, Moyed ; Kavanagh, Brian D. ; Diot, Quentin ; Westerly, David C. ; Schefter, Tracey E. |
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Zeitschrift: | International Journal of Radiation Oncology*Biology*Physics, Jg. 84 (2012-11-01), S. e441- (6S.) |
Veröffentlichung: | Elsevier BV, 2012 |
Medientyp: | unknown |
ISSN: | 0360-3016 (print) |
DOI: | 10.1016/j.ijrobp.2012.04.041 |
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