Engagement Rules That Underpin DBL-DARC Interactions for Ingress of Plasmodium knowlesi and Plasmodium vivax Into Human Erythrocytes
In: Frontiers in Molecular Biosciences, Jg. 5 (2018-08-27)
Online
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Zugriff:
Malaria parasite erythrocytic stages comprise of repeated bursts of parasites via cyclical invasion of host erythrocytes using dedicated receptor-ligand interactions. A family of erythrocyte-binding proteins from Plasmodium knowlesi (Pk) and Plasmodium vivax (Pv) attach to human Duffy antigen receptor for chemokines (DARC) via their Duffy binding-like domains (DBLs) for invasion. Here we provide a novel, testable and overarching interaction model that rationalizes even contradictory pieces of evidence that have so far existed in the literature on Pk/Pv-DBL/DARC binding determinants. We further address the conundrum of how parasite-encoded Pk/Pv-DBLs recognize human DARC and collate evidence for two distinct DARC integration sites on Pk/Pv-DBLs.
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Engagement Rules That Underpin DBL-DARC Interactions for Ingress of Plasmodium knowlesi and Plasmodium vivax Into Human Erythrocytes
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Autor/in / Beteiligte Person: | Yogavel, Manickam ; Sharma, Amit ; Gupta, Swati ; Chhibber-Goel, Jyoti ; Jamwal, Abhishek |
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Zeitschrift: | Frontiers in Molecular Biosciences, Jg. 5 (2018-08-27) |
Veröffentlichung: | Frontiers Media SA, 2018 |
Medientyp: | unknown |
ISSN: | 2296-889X (print) |
DOI: | 10.3389/fmolb.2018.00078 |
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