Duet is a novel serine/threonine kinase with Dbl-Homology (DH) and Pleckstrin-Homology (PH) domains
In: Gene, Jg. 227 (1999-02-01), S. 249-255
Online
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Zugriff:
We show here the identification of Duet, a novel molecule bearing serine/threonine kinase, Dbl-Homology (DH), and Pleckstrin-Homology (PH) domains. The kinase domain of Duet shows a homology to that of DAP kinase that is involved in apoptosis, and Duet is autophosphorylated by an in-vitro kinase assay. The DH- and PH-domains are closely related to those of Trio and Kalirin. Duet mRNA is specifically expressed in skeletal muscle. Duet protein was localized to actin-associated cytoskeletal elements. These data suggest a role of Duet in the cytoskeleton-dependent cell function.
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Duet is a novel serine/threonine kinase with Dbl-Homology (DH) and Pleckstrin-Homology (PH) domains
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Autor/in / Beteiligte Person: | Sanjo, Hideki ; Akira, Shizuo ; Kawai, Taro |
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Zeitschrift: | Gene, Jg. 227 (1999-02-01), S. 249-255 |
Veröffentlichung: | Elsevier BV, 1999 |
Medientyp: | unknown |
ISSN: | 0378-1119 (print) |
DOI: | 10.1016/s0378-1119(98)00605-2 |
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