Dietary and lifestyle factors in multiple sclerosis progression: results from a 5-year longitudinal MRI study
In: Journal of neurology, Jg. 266 (2018-08-14), Heft 4
Online
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Zugriff:
Evidence regarding the role, if any, of dietary and lifestyle factors in the pathogenesis of multiple sclerosis (MS) is poorly understood. To assess the effect of lifestyle-based risk factors linked to cardiovascular disease (CVD) on clinical and MRI-derived MS outcomes. The study enrolled 175 MS or clinically isolated syndrome (CIS) patients and 42 age- and sex-matched healthy controls (HCs) who were longitudinally followed for 5.5 years. The 20-year CVD risk was calculated by Healthy Heart Score (HHS) prediction model which includes age, smoking, body mass index, dietary intake, exercise, and alcohol consumption. Baseline and follow-up MRI scans were obtained and cross-sectional and longitudinal changes of T2-lesion volume (LV), whole brain volume (WBV), white matter volume (WMV), gray matter volume (GMV), and lateral ventricular volume (LVV) were calculated. After correcting for disease duration, the baseline HHS values of the MS group were associated with baseline GMV (rs = − 0.20, p = 0.01), and longitudinal LVV change (rs = 0.19, p = 0.01). The association with LVV remained significant after adjusting for baseline LVV volumes (rs = 0.2, p = 0.008) in MS patients. The diet component of the HHS was associated with the 5-year T2-LV accrual (rs = − 0.191, p = 0.04) in MS. In the HC group, the HHS was associated with LVV (rs = 0.58, p
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Dietary and lifestyle factors in multiple sclerosis progression: results from a 5-year longitudinal MRI study
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Autor/in / Beteiligte Person: | Bergsland, Niels ; Fuchs, Tom A. ; Hagemeier, Jesper ; Dwyer, Michael G. ; Guan, Yi ; Browne, Richard W. ; Ramanathan, Murali ; Zivadinov, Robert ; Ramasamy, Deepa P. ; Weinstock-Guttman, Bianca ; Jakimovski, Dejan ; Gandhi, Sirin |
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Zeitschrift: | Journal of neurology, Jg. 266 (2018-08-14), Heft 4 |
Veröffentlichung: | 2018 |
Medientyp: | unknown |
ISSN: | 1432-1459 (print) |
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