Diamidophosphate (DAP): A Plausible Prebiotic Phosphorylating Reagent with a Chem to BioChem Potential?

Known since the 1890s, diamidophosphate (DAP) has been investigated within the context of its inorganic chemistry. In 1999 – with the demonstration of DAP's potential as a phosphorylating agent of sugars in aqueous medium – began the exciting phase of research about DAP's role as a plausible prebiotic phosphorylating agent. More recently, in the last five years, there has been a steady increase in the publications that have documented the surprising versatility of DAP enabling the emergence of many classes of biomolecules of life, such as nucleic acids, peptides and protocells. Thus, though in its infancy, DAP seems to be uniquely positioned to play a central role in modelling abiotic‐ to prebiotic‐chemical evolution. In this context, there is a need for systematic investigations for: (a) establishing DAP's likely availability on the early Earth, and (b) developing DAP's potential as a tool for use in synthetic and bioorganic chemistry.

Diamidophosphate (DAP), a di‐nitrogenous analogue of orthophosphate, is a versatile phosphorylating‐activating reagent and amine source in the context of aqueous prebiotic chemistry compatible with both prebiotic‐ and bio‐molecules. The promising potential of this reagent, enabling a continuous transition from abiotic‐to‐biotic needs to be investigated both from its geochemical provenance and its applicability to (bio)organic transformations.