Risk factors for chronic mucus hypersecretion in individuals with and without COPD: influence of smoking and job exposure on CMH
In: Occupational and Environmental Medicine, 71(5), 346. BMJ Publishing Group Ltd Occupational & Environmental Medicine, 71(5), 346-352; (2014)
Online
unknown
Zugriff:
Background Chronic mucus hypersecretion (CMH) is highly prevalent in smokers and associated with an accelerated lung function decline and chronic obstructive pulmonary disease (COPD). Several risk factors contribute to CMH and to COPD. It is, however, unknown if risk factors for CMH are similar in persons with and without COPD.Methods 1479 persons with and 8529 without COPD, participating in the general population-based LifeLines cohort, completed questionnaires and underwent spirometry. Occupational exposure was assessed using the ALOHA+ job exposure matrix. Analyses were performed using multiple logistic regression models.Results In COPD, a significantly higher risk for CMH was associated with higher pack-years smoking (per 10 pack-years) (OR=1.28; 1.12 to 1.46) and environmental tobacco smoke (ETS) (OR=2.06; 1.33 to 3.19). In non-COPD; male gender (OR=1.91; 1.51 to 2.41), higher Body Mass Index (OR=1.04; 1.01 to 1.06), higher pack-years smoking (OR=1.28; 1.14 to 1.44), current smoking (OR=1.50; 1.04 to 2.18), low and high exposure to mineral dust (OR=1.39; 1.04 to 1.87 and OR=1.60; 1.02 to 2.52), high exposure to gases & fumes (OR=2.19; 1.49 to 3.22). Significant interactions were found between COPD and exposure to gases & fumes (p=0.018) and aromatic solvents (p=0.038).Conclusions A higher risk for CMH was associated with higher pack-years smoking regardless of COPD status. However, a higher risk for CMH was associated with high occupational exposure to gases & fumes in individuals without COPD only.
Titel: |
Risk factors for chronic mucus hypersecretion in individuals with and without COPD: influence of smoking and job exposure on CMH
|
---|---|
Autor/in / Beteiligte Person: | Postma, Dirkje S. ; Kromhout, Hans ; Vonk, Judith M. ; Dijkstra, Akkelies E. ; Vermeulen, Roel ; Kim de Jong ; Harry J.M. Groen ; H. Marike Boezen ; LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.) ; LS IRAS EEPI GRA (Gezh.risico-analyse) ; Risk Assessment of Toxic and Immunomodulatory Agents ; RATIA-SIB, IRAS ; RATIA2, IRAS ; Groningen Research Institute for Asthma and COPD (GRIAC) ; Damage and Repair in Cancer Development and Cancer Treatment (DARE) ; Life Course Epidemiology (LCE) ; Guided Treatment in Optimal Selected Cancer Patients (GUTS) |
Link: | |
Quelle: | Occupational and Environmental Medicine, 71(5), 346. BMJ Publishing Group Ltd Occupational & Environmental Medicine, 71(5), 346-352; (2014) |
Veröffentlichung: | 2014 |
Medientyp: | unknown |
ISSN: | 1351-0711 (print) ; 1470-7926 (print) |
Schlagwort: |
|
Sonstiges: |
|