Detection of macrophage inflammatory protein (MIP)-1alpha and MIP-1beta during experimental endotoxemia and human sepsis
In: The Journal of infectious diseases, Jg. 179 (1998-12-08), Heft 1
Online
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Zugriff:
Macrophage inflammatory protein (MIP)-1alpha and MIP-1beta regulate leukocyte activation and trafficking. To assess the role of MIP-1alpha and MIP-1beta in human inflammation, healthy subjects were studied during experimental endotoxemia with prior administration of ibuprofen, a cyclooxygenase inhibitor, or dimeric p75 tumor necrosis factor (TNF)-alpha receptor, a TNF antagonist; septic patients were also studied. Following endotoxin, blood levels of both MIP-1 molecules rose acutely and fell to baseline by 6 h (P=. 001). While MIP-1 mediates fever in animals independent of cyclooxygenase blockade, in subjects given endotoxin and ibuprofen, MIP-1 levels increased and fever was suppressed. MIP-1 levels were not diminished by inhibiting circulating TNF-alpha in humans. In septic patients, elevated levels of MIP-1alpha and MIP-1beta were detected within 24 h of sepsis and fell in parallel with TNF-alpha and interleukin-6 (P
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Detection of macrophage inflammatory protein (MIP)-1alpha and MIP-1beta during experimental endotoxemia and human sepsis
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Autor/in / Beteiligte Person: | Reda, Debra ; Suffredini, Anthony F. ; Banks, Steven M. ; O'Grady, Naomi P. ; Tropea, Margaret ; R. William Vandivier ; Preas, Hugh L. |
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Zeitschrift: | The Journal of infectious diseases, Jg. 179 (1998-12-08), Heft 1 |
Veröffentlichung: | 1998 |
Medientyp: | unknown |
ISSN: | 0022-1899 (print) |
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