Two-year outcomes following unprotected left main stenting with first vs. new-generation drug-eluting stents: the FINE registry
In: EuroIntervention, Jg. 9 (2013-11-01), S. 809-816
Online
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Zugriff:
AIMS To assess two-year outcomes following first vs. new-generation drug-eluting stent (DES) implantation in unprotected left main (ULMCA) percutaneous coronary intervention. METHODS AND RESULTS All eligible patients from our two-centre registry treated with first and new-generation DES from October 2006 to November 2010 were analysed. The study objective was major adverse cardiac events (MACE), defined as all-cause mortality, target vessel revascularisation (TVR) and myocardial infarction (MI) at two years. In total, 186 patients were included: 93 (50.0%) treated with first vs. 93 (50.0%) with new-generation DES. No differences were observed in baseline clinical characteristics except for higher EuroSCORE with new-generation DES (3.6±2.5 vs. 4.6±2.7; p=0.007). No significant difference was observed in stenting techniques; two stents were used respectively in 53.8% vs. 44.1% (p=0.187). Notably, intravascular ultrasound guidance was more frequent with new-generation DES (46.2% vs. 61.3%; p=0.040). At 730.0 (interquartile range 365.5-1,224.5) days, there was a trend towards improved MACE with new-generation DES (31.2% vs. 19.6%; p=0.070) and a significant reduction in TVR (23.7% vs. 12.0%; p=0.038) and MI (4.3% vs. 0%; p=0.044). Notably, there were four cases of definite stent thrombosis (ST) with first vs. none with new-generation DES (p=0.044). CONCLUSIONS In our study, new-generation DES had a trend for less MACE and improved results with regard to MI, TVR and definite ST at two-year follow-up.
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Two-year outcomes following unprotected left main stenting with first vs. new-generation drug-eluting stents: the FINE registry
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Autor/in / Beteiligte Person: | Figini, Filippo ; Latib, Azeem ; Carlino, Mauro ; Montorfano, Matteo ; Durante, Alessandro ; Giannini, Francesco ; Castelli, Alfredo ; Ielasi, Alfonso ; Bernelli, Chiara ; Colombo, Antonio ; Gill Louise Buchanan ; Chieffo, Alaide |
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Zeitschrift: | EuroIntervention, Jg. 9 (2013-11-01), S. 809-816 |
Veröffentlichung: | Europa Digital & Publishing, 2013 |
Medientyp: | unknown |
ISSN: | 1774-024X (print) |
DOI: | 10.4244/eijv9i7a134 |
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