Persistent CMV infection after allogeneic hematopoietic stem cell transplantation in a CMV-seronegative donor-to-positive recipient constellation: Development of multidrug resistance in the absence of anti-viral cellular immunity
In: Journal of Clinical Virology, Jg. 74 (2016), S. 57-60
Online
unknown
Zugriff:
We describe a case of persistent cytomegalovirus (CMV) infection after allogeneic hematopoietic stem cell transplantation (allo-HSCT) with discordant and high-risk (D-/R+) constellation of CMV serostatus. Despite the use of different and innovative antiviral strategies, viral replication could not be suppressed successfully promoting a protracted CMV colitis associated with severe gastrointestinal graft-versus-host disease (GI GVHD). We illustrate that the development of multidrug viral resistance, the failure to mount a CMV-specific cellular immune response, as confirmed by QuantiFERON(®)-CMV (Qiagen) assay, and the refractory GVHD requiring prolonged immunosuppression were the main factors contributing to persistent viral replication and the fulminant unfavorable course.
Titel: |
Persistent CMV infection after allogeneic hematopoietic stem cell transplantation in a CMV-seronegative donor-to-positive recipient constellation: Development of multidrug resistance in the absence of anti-viral cellular immunity
|
---|---|
Autor/in / Beteiligte Person: | Holtick, Udo ; Schröder, L. ; Chakupurakal, Geothy ; Scheid, Christof ; Herling, Marco ; Kaiser, Rolf ; Pfister, Herbert ; Awerkiew, Sabine ; Veronica Di Cristanziano |
Link: | |
Zeitschrift: | Journal of Clinical Virology, Jg. 74 (2016), S. 57-60 |
Veröffentlichung: | Elsevier BV, 2016 |
Medientyp: | unknown |
ISSN: | 1386-6532 (print) |
DOI: | 10.1016/j.jcv.2015.11.033 |
Schlagwort: |
|
Sonstiges: |
|