Multicenter phase II study of oral capecitabine plus irinotecan as first-line chemotherapy in advanced colorectal cancer: A Korean Cancer Study Group Trial
In: Acta Oncologica, Jg. 44 (2005-05-01), S. 230-235
Online
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Zugriff:
A phase II study was conducted to assess the efficacy and tolerability of capecitabine in combination with irinotecan (CAPIRI) in advanced colorectal cancer. Forty-seven patients with previously untreated metastatic or unresectable colorectal adenocarcinoma received capecitabine 1000 mg/m2 twice daily on days 2-15 and intravenous irinotecan 100 mg/m2 on days 1 and 8, every 21 days. A total of 268 cycles of chemotherapy (median 6: range 1-11) were administered. According to an intent-to-treat analysis, the overall response rate was 49% (95% CI, 35-63%). Median time to progression and overall survival were 7.5 months (95% CI, 4.8-10.2) and 19.5 months (95% CI, 15.7-23.8), respectively. The most common grade 3/4 adverse events were diarrhea (24%) and neutropenia (11%). There were no treatment-related deaths. These results indicate that CAPIRI has comparable activity and tolerability to FOLFIRI as first-line treatment for advanced colorectal cancer.
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Multicenter phase II study of oral capecitabine plus irinotecan as first-line chemotherapy in advanced colorectal cancer: A Korean Cancer Study Group Trial
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Autor/in / Beteiligte Person: | Kyung Hee Lee ; Kim, Hoon-Kyo ; Joon Oh Park ; Kang, Yoon-Koo ; Tae Won Kim ; Heung Moon Chang ; Dae Young Zang ; Baek Yeol Ryoo ; Won Ki Kang ; Jin Seok Ahn ; Sung Rok Kim |
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Zeitschrift: | Acta Oncologica, Jg. 44 (2005-05-01), S. 230-235 |
Veröffentlichung: | Informa UK Limited, 2005 |
Medientyp: | unknown |
ISSN: | 1651-226X (print) ; 0284-186X (print) |
DOI: | 10.1080/02841860510029590 |
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