Brain-computer-interface-based intervention re-normalizes brain functional network topology in children with attention deficit/hyperactivity disorder
In: Translational Psychiatry, Jg. 8 (2018), Heft 1, S. 1-11
Online
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Zugriff:
A brain-computer-interface (BCI)-based attention training game system has shown promise for treating attention deficit/hyperactivity disorder (ADHD) children with inattentive symptoms. However, little is known about brain network organizational changes underlying behavior improvement following BCI-based training. To cover this gap, we aimed to examine the topological alterations of large-scale brain functional networks induced by the 8-week BCI-based attention intervention in ADHD boys using resting-state functional magnetic resonance imaging method. Compared to the non-intervention (ADHD-NI) group, the intervention group (ADHD-I) showed greater reduction of inattention symptoms accompanied with differential brain network reorganizations after training. Specifically, the ADHD-NI group had increased functional connectivity (FC) within the salience/ventral attention network (SVN) and increased FC between task-positive networks (including the SVN, dorsal attention (DAN), somatomotor, and executive control network) and subcortical regions; in contrast ADHD-I group did not have this pattern. In parallel, ADHD-I group had reduced degree centrality and clustering coefficient as well as increased closeness in task-positive and the default mode networks (prefrontal regions) after the training. More importantly, these reduced local functional processing mainly in the SVN were associated with less inattentive/internalizing problems after 8-week BCI-based intervention across ADHD patients. Our findings suggest that the BCI-based attention training facilitates behavioral improvement in ADHD children by reorganizing brain functional network from more regular to more random configurations, particularly renormalizing salience network processing. Future long-term longitudinal neuroimaging studies are needed to develop the BCI-based intervention approach to promote brain maturation in ADHD. NMRC (Natl Medical Research Council, S’pore) MOH (Min. of Health, S’pore) Published version
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Brain-computer-interface-based intervention re-normalizes brain functional network topology in children with attention deficit/hyperactivity disorder
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Autor/in / Beteiligte Person: | Xue Wei Wendy Poh ; Zhou, Juan ; Qian, Xing ; Chee, Michael W. L. ; Beatrice Rui Yi Loo ; Hui Li Koh ; Fung, Daniel ; Lee, Tih-Shih ; Castellanos, Francisco X. ; Liu, Siwei ; Krishnan, Ranga ; Choon Guan Lim ; Guan, Cuntai ; School of Computer Science and Engineering |
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Zeitschrift: | Translational Psychiatry, Jg. 8 (2018), Heft 1, S. 1-11 |
Veröffentlichung: | Springer Science and Business Media LLC, 2018 |
Medientyp: | unknown |
ISSN: | 2158-3188 (print) |
DOI: | 10.1038/s41398-018-0213-8 |
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