Oral Pharmacokinetics of Bisoprolol in Resting and Exercising Healthy Volunteers
In: Journal of Cardiovascular Pharmacology, Jg. 18 (1991-07-01), S. 28-34
Online
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Zugriff:
The effects of exercise on bisoprolol oral pharmacokinetics were studied in eight healthy male volunteers in an open, randomized, three-period, crossover trial. Oral bisoprolol (20 mg) was given either at rest during 24 h or with iterative stress tests before and 2.5, 5, 10, and 24 h after dosing. Exercise tests were repeated on a third placebo period. Bisoprolol was assayed in plasma and urines, and plasma catecholamines were measured before and after stress tests, Cmax, Tmax, elimination t1/2, and renal clearance of bisoprolol were not significantly modified by exercise. AUC0-infinity significantly decreased by 7.5% (p less than 0.05) with stress test resulting in an increase in apparent oral clearance. The beta-blocking effect peaked at 2.5 h, lasted greater than 24 h, and was related to plasma levels. The exercise-induced increase in plasma norepinephrine levels was significantly augmented with bisoprolol. These results suggest that repeated exercise tests exerted only limited effects on the oral pharmacokinetics of bisoprolol.
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Oral Pharmacokinetics of Bisoprolol in Resting and Exercising Healthy Volunteers
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Autor/in / Beteiligte Person: | Jaillon, Patrice ; Lecocq, B. ; Sauleman, P ; Rames, A ; J L Cuche ; Poirier, Jean-Marie ; F Le Coz ; Midavaine, M |
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Zeitschrift: | Journal of Cardiovascular Pharmacology, Jg. 18 (1991-07-01), S. 28-34 |
Veröffentlichung: | Ovid Technologies (Wolters Kluwer Health), 1991 |
Medientyp: | unknown |
ISSN: | 0160-2446 (print) |
DOI: | 10.1097/00005344-199107000-00005 |
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