Spinal cord stimulation in experimental chronic painful diabetic polyneuropathy
In: European Journal of Pain, Jg. 21 (2017-05-01), Heft 5, S. 795-803
Online
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Zugriff:
Background Spinal cord stimulation (SCS) has been shown to provide pain relief in painful diabetic polyneuropathy (PDPN). As the vasculature system plays a great role in the pathophysiology of PDPN, a potential beneficial side-effect of SCS is peripheral vasodilation, with high frequency (HF) SCS in particular. We hypothesize that HF-SCS (500 Hz), compared with conventional (CON) or low frequency (LF)-SCS will result in increased alleviation of mechanical hypersensitivity in chronic experimental PDPN. Methods Diabetes was induced in 8-week-old female Sprague–Dawley rats with an intraperitoneal injection of 65 mg/kg of streptozotocin (n = 44). Rats with a significant decrease in mechanical withdrawal response to von Frey filaments over a period of 20 weeks were implanted with SCS electrodes (n = 18). Rats were assigned to a cross-over design with a random order of LF-, CON-, HF- and sham SCS and mechanical withdrawal thresholds were assessed with von Frey testing. Results Compared with sham treatment, the average 50% WT score for 5 Hz was 4.88 g higher during stimulation (p = 0.156), and 1.77 g higher post-stimulation (p = 0.008). CON-SCS resulted in 50% WT scores 5.7 g, and 2.51 g higher during (p = 0.064) and after stimulation (p
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Spinal cord stimulation in experimental chronic painful diabetic polyneuropathy
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Autor/in / Beteiligte Person: | Linderoth, Bengt ; M. van Beek ; M. van Kleef ; S.M.J. van Kuijk ; Elbert A.J. Joosten ; Honig, Wiel ; Anesthesiologie ; RS: MHeNs - R3 - Neuroscience ; Promovendi, MHN ; MUMC+: CAKZ Pijnkennis Ane (9) ; MUMC+: MA Anesthesiologie (9) ; MUMC+: KIO Kemta (9) ; Ondersteunend personeel, MHN |
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Zeitschrift: | European Journal of Pain, Jg. 21 (2017-05-01), Heft 5, S. 795-803 |
Veröffentlichung: | 2017 |
Medientyp: | unknown |
ISSN: | 1090-3801 (print) |
DOI: | 10.1002/ejp.981 |
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