Temporal phases of long-term potentiation (LTP): myth or fact?
In: Reviews in the Neurosciences, Jg. 26 (2015-10-01), S. 507-546
Online
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Zugriff:
Long-term potentiation (LTP) remains the most widely accepted model for learning and memory. In accordance with this belief, the temporal differentiation of LTP into early and late phases is accepted as reflecting the differentiation of short-term and long-term memory. Moreover, during the past 30 years, protein synthesis inhibitors have been used to separate the early, protein synthesis-independent (E-LTP) phase and the late, protein synthesis-dependent (L-LTP) phase. However, the role of these proteins has not been formally identified. Additionally, several reports failed to show an effect of protein synthesis inhibitors on LTP. In this review, a detailed analysis of extensive behavioral and electrophysiological data reveals that the presumed correspondence of LTP temporal phases to memory phases is neither experimentally nor theoretically consistent. Moreover, an overview of the time courses of E-LTP in hippocampal slices reveals a wide variability ranging from de novosynthesis of plasticity-related proteins. This availability is determined by protein turnover kinetics, which is regulated by previous and ongoing electrical activities and by energy store availability.
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Temporal phases of long-term potentiation (LTP): myth or fact?
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Autor/in / Beteiligte Person: | Ris, Laurence ; Abbas, Abdul-Karim ; Villers, Agnès |
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Zeitschrift: | Reviews in the Neurosciences, Jg. 26 (2015-10-01), S. 507-546 |
Veröffentlichung: | Walter de Gruyter GmbH, 2015 |
Medientyp: | unknown |
ISSN: | 2191-0200 (print) ; 0334-1763 (print) |
DOI: | 10.1515/revneuro-2014-0072 |
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