lnc-HOTAIR predicts hepatocellular carcinoma in chronic hepatitis C genotype 4 following direct-acting antivirals therapy
In: Molecular carcinogenesisREFERENCES, Jg. 59 (2020-08-15), Heft 12
Online
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Zugriff:
Emerging hepatocellular carcinoma (HCC) has been sequentially reported in chronic hepatitis C virus (HCV) treated with direct-acting antivirals (DAAs). Homeobox transcript antisense RNA (HOTAIR), an oncogene, has been reported to be associated with cancer. We investigated the predictive value of lnc-HOTAIR for HCC surveillance in chronic HCV patients following DAAs therapy. The expression levels of lnc-HOTAIR and ATG-7 genes were measured in 220 with chronic HCV, following a DAAs based therapy for 12 weeks, the patients were followed-up for attentive surveillance of HCC for 12 months after starting DAAs. In terms of lnc-HOTAIR, patients with HCC and high viral load had significantly higher median expression levels of HOTAIR of (68 vs. 24; p = .001) and (94 vs. 52; p = .001), respectively. Moreover, the median expression level of ATG-7 was higher in those who developed HCC (114 vs. 51; p = .001). The expression of lnc-HOTAIR and ATG-7 are significant predictors of the development of HCC in HCV-4 infected patients treated with DAAs, with a cut-off value of 37 and 86, respectively. The increased expression levels of lnc-HOTAIR more than 68 in HCC patients following DAAs were correlated with poorer disease outcomes compared to those with lower expression levels; however, ATG-7 expression levels more than 114 were correlated with worse overall survival but not the progression-free one. We suggest that high expression levels of lnc-HOTAIR could serve as a risk assessment biomarker for HCC before and during DAAs course therapy in Chronic HCV-4 patients, and should be rigorously taken into consideration before DAAs.
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lnc-HOTAIR predicts hepatocellular carcinoma in chronic hepatitis C genotype 4 following direct-acting antivirals therapy
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Autor/in / Beteiligte Person: | Hekmat M. El Magdoub ; Mohamed Hafez Shaaban ; Hoda H Abou Gabal ; El-Khazragy, Nashwa ; Ghozy, Sherief ; Bayoumi, Ahmed ; Bannunah, Azzah M. ; Elshimy, Amal A. ; Aboelhussein, Marwa M. ; Gaballah, Ahmed ; Azza El‐Sayed Mansy ; Hassan, Safaa S. |
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Zeitschrift: | Molecular carcinogenesisREFERENCES, Jg. 59 (2020-08-15), Heft 12 |
Veröffentlichung: | 2020 |
Medientyp: | unknown |
ISSN: | 1098-2744 (print) |
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