Outcome in Patients Treated with Intra-arterial thrombectomy: The optiMAL Blood Pressure control (OPTIMAL-BP) Trial
In: International Journal of Stroke, Jg. 17 (2021-08-29), S. 931-937
Online
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Zugriff:
Rationale Very early stage blood pressure (BP) levels may affect outcome in stroke patients who have successfully undergone recanalization following intra-arterial treatment, but the optimal target of BP management remains uncertain. Aim We hypothesized that the clinical outcome after intensive BP-lowering is superior to conventional BP control after successful recanalization by intra-arterial treatment. Sample-size estimates We aim to randomize 668 patients (334 per arm), 1:1. Methods and design We initiated a multicenter, prospective, randomized, open-label trial with a blinded end-point assessment (PROBE) design. After successful recanalization (thrombolysis in cerebral infarction score ≥ 2 b), patients with elevated systolic BP level, defined as the mean of two readings ≥ 140 mmHg, will be randomly assigned to the intensive BP-lowering (systolic BP Study outcomes The primary efficacy outcomes are from dichotomized analysis of modified Rankin Scale (mRS) scores at three months (mRS scores: 0–2 vs. 3–6). The primary safety outcomes are symptomatic intracerebral hemorrhage and death within three months. Discussion The OPTIMAL-BP trial will provide evidence for the effectiveness of active BP control to achieve systolic BP Clinical trial registration ClinicalTrials.gov Identifier: NCT04205305.
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Outcome in Patients Treated with Intra-arterial thrombectomy: The optiMAL Blood Pressure control (OPTIMAL-BP) Trial
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Autor/in / Beteiligte Person: | Hyo Suk Nam ; Jin Kyo Choi ; Chang, Yoonkyung ; Seo, Kwon-Duk ; Cho, Bang-Hoon ; Lee, Hye S. ; Baik, Minyoul ; Seong Hwan Ahn ; Yo Han Jung ; Tae Jin Song ; Jun Young Chang ; Heo, JoonNyung ; Park, Sungha ; Dong Joon Kim ; Cho, Han-Jin ; Chung, Jong-Won ; Jung Hwa Seo ; Gyu Sik Kim ; Park, Goeun ; Chan Joo Lee ; Park, Hyungjong ; Sung Il Sohn ; Jang Hyun Baek ; Lee, Jun ; Jae Guk Kim ; Seo, Woo-Keun ; Kim, Jinkwon ; Yoo, Joonsang ; Hong, Jeong-Ho ; Oh Young Bang ; Byung Moon Kim ; Hwang, Yang-Ha ; Lee, Kijeong ; Lee, Kyung-Yul ; Dong Hoon Shin ; Kwon, Sun U. ; Chi Kyung Kim ; Young Dae Kim |
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Zeitschrift: | International Journal of Stroke, Jg. 17 (2021-08-29), S. 931-937 |
Veröffentlichung: | SAGE Publications, 2021 |
Medientyp: | unknown |
ISSN: | 1747-4949 (print) ; 1747-4930 (print) |
DOI: | 10.1177/17474930211041213 |
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