IL-23 plasma level is strongly associated with CMV status and reactivation of CMV in renal transplant recipients
In: BMC Immunology, Jg. 17 (2016-10-03)
Online
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Zugriff:
Background: Cytomegalovirus seropositivity is an independent risk factor for atherosclerosis in patients with ESRD. Donor CMV seropositivity is associated with higher graft loss. Dendritic cells, macrophages and Th17 lymphocytes are defined as producers of IL-23. IL-23 is thought to be involved in the promotion of Th17 cell polarization. Latent CMV-induced Th17 might be involved in the pathogenesis of CMV infection in patients with ESRD. We aimed to evaluate associations of Th17-dependent cytokines with ESRD, CMV status and post-transplant outcome in kidney transplantation. Results: IL-21 plasma levels were similar in patients and healthy controls (p = 0.47), whereas IL-9 (p = 0.02) and IL-23 (p
| Titel: |
IL-23 plasma level is strongly associated with CMV status and reactivation of CMV in renal transplant recipients
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| Autor/in / Beteiligte Person: | Lahdou, Imad ; Zeier, Martin ; Opelz, Gerhard ; Daniel, Volker ; Sadeghi, Mahmoud ; Mehrabi, Arianeb ; Schnitzler, Paul |
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| Zeitschrift: | BMC Immunology, Jg. 17 (2016-10-03) |
| Veröffentlichung: | Springer Science and Business Media LLC, 2016 |
| Medientyp: | unknown |
| ISSN: | 1471-2172 (print) |
| DOI: | 10.1186/s12865-016-0175-7 |
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