A deterministic model of admixture and genetic introgression: the case of Neanderthal and Cro-Magnon
In: Mathematical Biosciences Mathematical Biosciences, Elsevier, 2008, 216 (1), pp.71-6. ⟨10.1016/j.mbs.2008.08.004⟩; (2008-11-01)
Online
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Zugriff:
International audience; There is an ongoing debate in the field of human evolution about the possible contribution of Neanderthals to the modern human gene pool. To study how the Neanderthal private alleles may have spread over the genes of Homo sapiens, we propose a deterministic model based on recursive equations and ordinary differential equations. If the Neanderthal population was large compared to the Homo sapiens population at the beginning of the contact period, we show that genetic introgression should have been fast and complete meaning that most of the Neanderthal private alleles should be found in the modern human gene pool in case of ancient admixture. In order to test/reject ancient admixture from genome-wide data, we incorporate the model of genetic introgression into a statistical hypothesis-testing framework. We show that the power to reject ancient admixture increases as the ratio, at the time of putative admixture, of the population size of Homo sapiens over that of Neanderthal decreases. We find that the power to reject ancient admixture might be particularly low if the population size of Homo sapiens was comparable to the Neanderthal population size.
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A deterministic model of admixture and genetic introgression: the case of Neanderthal and Cro-Magnon
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Autor/in / Beteiligte Person: | Martiel, Jean-Louis ; Blum, Michael G. B. ; Forhan, Gerald ; TIMB ; Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG) ; VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF) |
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Quelle: | Mathematical Biosciences Mathematical Biosciences, Elsevier, 2008, 216 (1), pp.71-6. ⟨10.1016/j.mbs.2008.08.004⟩; (2008-11-01) |
Veröffentlichung: | HAL CCSD, 2008 |
Medientyp: | unknown |
ISSN: | 0025-5564 (print) |
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