A Cluster of Strong Topoisomerase II Cleavage Sites is Located Near an Integrated Human Immunodeficiency Virus
In: Journal of Molecular Biology, Jg. 232 (1993-08-01), S. 1060-1068
Online
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Zugriff:
The Human Immunodeficiency Virus (HIV) integrates into host cellular DNA as a double strand DNA molecule. Here a previously studied HIV isolate was examined for binding and cleavage by topoisomerase II in vitro within the 5' LTR region and human flanking DNA. A cluster of strong binding and cleavage sites in the human sequences was located approximately 850 bp upstream from the integration site. This region maps to a locus consisting of a complex repeating element, and alternating purine/pyrimidine sequences. Topoisomerase II binding and cleavage sites were also located within the HIV 5' LTR, in particular a site overlying the DNA sequence coding for TAR, another inverted repeat element in the DNA.
Titel: |
A Cluster of Strong Topoisomerase II Cleavage Sites is Located Near an Integrated Human Immunodeficiency Virus
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Autor/in / Beteiligte Person: | Howard, Michael T. ; Griffith, Jack D. |
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Zeitschrift: | Journal of Molecular Biology, Jg. 232 (1993-08-01), S. 1060-1068 |
Veröffentlichung: | Elsevier BV, 1993 |
Medientyp: | unknown |
ISSN: | 0022-2836 (print) |
DOI: | 10.1006/jmbi.1993.1460 |
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