Outcomes in elderly patients treated with a single-agent or combination regimen as first-line chemotherapy for recurrent or metastatic gastric cancer
In: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, Jg. 18 (2014-03-24), Heft 3
Online
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Zugriff:
Palliative chemotherapy is used to prolong survival among elderly patients with inoperable gastric cancer (GC). We analyzed differences between single and combination first-line palliative chemotherapy among these patients. Included patients were >70 years old and were treated for GC at four clinical centers of the Catholic University of Korea. Baseline characteristics, the first-line chemotherapy regimen, treatment responses, toxicities, progression-free survival (PFS), and overall survival (OS) were evaluated. Between 2005 and 2012, 178 > 70-year-old patients with GC received palliative chemotherapy using single or combination regimens. Median ages were 77 years (range 71–89) in the single regimen group (SG, 70 patients) and 73 years (range 71–81) in the combination group (CG, 108 patients). Patients in the SG received S-1 or capecitabine. The most common regimen in the CG was platinum combined with fluorouracil. The most common response in both groups was stable disease (SG, 45.7 %; CG, 48.1 %). In the SG and CG, median PFS times were 4.4 months (95 % confidence interval [CI] 2.85–5.95) and 4.1 months (95 % CI 2.62–5.57; P = 0.295), respectively; median OS times were 6.6 months (95 % CI 4.17–9.08) and 7.6 months (95 % CI 5.50–9.69; P = 0.782), respectively. Hematologic (P
Titel: |
Outcomes in elderly patients treated with a single-agent or combination regimen as first-line chemotherapy for recurrent or metastatic gastric cancer
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Autor/in / Beteiligte Person: | Der Sheng Sun ; Eun Kyoung Jeon ; Hoon Kyo Kim ; Hye Sung Won ; Byoung Young Shim ; Yoon Ho Ko ; Ji Chan Park ; Young Seon Hong ; Suk Young Park |
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Zeitschrift: | Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, Jg. 18 (2014-03-24), Heft 3 |
Veröffentlichung: | 2014 |
Medientyp: | unknown |
ISSN: | 1436-3305 (print) |
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