NLRP7 Promotes Choriocarcinoma Growth and Progression through the Establishment of an Immunosuppressive Microenvironment
In: Cancers Cancers, MDPI, 2021, 13 (12), pp.2999. ⟨10.3390/cancers13122999⟩, Jg. 13 (2021-06-01), Heft 2999, p 2999
Online
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Zugriff:
The inflammatory gene NLRP7 is the major gene responsible for recurrent complete hydatidiform moles (CHM), an abnormal pregnancy that can develop into gestational choriocarcinoma (CC). However, the role of NLRP7 in the development and immune tolerance of CC has not been investigated. Three approaches were employed to define the role of NLRP7 in CC development: (i) a clinical study that analyzed human placenta and sera collected from women with normal pregnancies, CHM or CC
(ii) an in vitro study that investigated the impact of NLRP7 knockdown on tumor growth and organization
and (iii) an in vivo study that used two CC mouse models, including an orthotopic model. NLRP7 and circulating inflammatory cytokines were upregulated in tumor cells and in CHM and CC. In tumor cells, NLRP7 functions in an inflammasome-independent manner and promoted their proliferation and 3D organization. Gravid mice placentas injected with CC cells invalidated for NLRP7, exhibited higher maternal immune response, developed smaller tumors, and displayed less metastases. Our data characterized the critical role of NLRP7 in CC and provided evidence of its contribution to the development of an immunosuppressive maternal microenvironment that not only downregulates the maternal immune response but also fosters the growth and progression of CC.
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NLRP7 Promotes Choriocarcinoma Growth and Progression through the Establishment of an Immunosuppressive Microenvironment
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| Autor/in / Beteiligte Person: | Murthi, Padma ; Roland Abi Nahed ; Reynaud, Deborah ; Sapin, Vincent ; Alfaidy, Nadia ; Battail, Christophe ; Benharouga, Mohamed ; Lemaitre, Nicolas ; Aboussaouira, Touria ; Bolze, Pierre-Adrien ; Traboulsi, Wael ; Slim, Rima ; Filhol, Odile ; Hoffmann, Pascale ; Boufettal, Houssine ; Sergent, Frederic ; BioSanté (UMR BioSanté) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG) ; Direction de Recherche Fondamentale (CEA) (DRF (CEA)) ; Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)) ; Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA) ; CEA- Saclay (CEA) ; Commissariat à l'énergie atomique et aux énergies alternatives (CEA) ; Physiologie cellulaire et végétale (LPCV) ; Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG) ; Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA) ; Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS) ; Hospices Civils de Lyon (HCL) ; Université Claude Bernard Lyon 1 (UCBL) ; Université de Lyon ; Georgetown University Medical Center ; Génétique, Reproduction et Développement (GReD) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA) ; Clermont-Ferrand, CHU ; Ibn Rochd University Hospital of Casablanca, University Hassan II of Casablanca, Morocco. ; Centre Hospitalier Universitaire [Grenoble] (CHU) ; Monash Biomedicine Discovery Institute ; Monash University [Clayton] ; University of Melbourne ; McGill University = Université McGill [Montréal, Canada] ; Mécanisme de l’Angiogenèseet des BarrièresBiologiques (MAB2) ; Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG) ; ANR-17-EURE-0003,CBH-EUR-GS,CBH-EUR-GS(2017) |
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| Zeitschrift: | Cancers Cancers, MDPI, 2021, 13 (12), pp.2999. ⟨10.3390/cancers13122999⟩, Jg. 13 (2021-06-01), Heft 2999, p 2999 |
| Veröffentlichung: | HAL CCSD, 2021 |
| Medientyp: | unknown |
| ISSN: | 2072-6694 (print) |
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