Immediate and Long-Term Outcomes of Reperfusion Therapy in Patients With Cancer
In: Stroke, Jg. 52 (2021-06-01), S. 2026-2034
Online
unknown
Zugriff:
Background and Purpose: Patients with acute stroke are often accompanied by comorbidities, such as active cancer. However, adequate treatment guidelines are not available for these patients. The purpose of this study was to evaluate the association between cancer and the outcomes of reperfusion therapy in patients with stroke. Methods: We compared treatment outcomes in patients who underwent reperfusion therapy, using a nationwide reperfusion therapy registry. We divided the patients into 3 groups according to cancer activity: active cancer, nonactive cancer, and without a history of cancer. We investigated reperfusion processes, 24-hour neurological improvement, adverse events, 3-month functional outcome, and 6-month survival and related factors after reperfusion therapy. Results: Among 1338 patients who underwent reperfusion therapy, 62 patients (4.6%) had active cancer, 78 patients (5.8%) had nonactive cancer, and 1198 patients (89.5%) had no history of cancer. Of the enrolled patients, 969 patients received intravenous thrombolysis and 685 patients underwent endovascular treatment (316 patients received combined therapy). Patients with active cancer had more comorbidities and experienced more severe strokes; however, they showed similar 24-hour neurological improvement and adverse events, including cerebral hemorrhage, compared with the other groups. Although the functional outcome at 3 months was poorer than the other groups, 36.4% of patients with active cancer showed functional independence. Additionally, 52.9% of the patients with determined stroke etiology showed functional independence despite active cancer. During the 6-month follow-up, 46.6% of patients with active cancer died, and active cancer was independently associated with poor survival (hazard ratio, 3.973 [95% CI, 2.528–6.245]). Conclusions: In patients with active cancer, reperfusion therapy showed similar adverse events and short-term outcomes to that of other groups. While long-term prognosis was worse in the active cancer group than the nonactive cancer groups, not negligible number of patients had good functional outcomes, especially those with determined stroke mechanisms.
Titel: |
Immediate and Long-Term Outcomes of Reperfusion Therapy in Patients With Cancer
|
---|---|
Autor/in / Beteiligte Person: | Seo, Woo-Keun ; Kim, Jinkwon ; Yoo, Joonsang ; Gyu Sik Kim ; Joong Hyun Park ; Dong Joon Kim ; Hyo Suk Nam ; Jin Kyo Choi ; Han, Euna ; Kim, Min-Young ; Hye Yeon Choi ; Seong Hwan Ahn ; Oh Young Bang ; Young Dae Kim ; Han Jin Cho ; Sang Won Han ; Sung Il Sohn ; Seo Hyun Kim ; Chung, Jong-Won ; Jang Hyun Baek ; Hye Sun Lee ; Sung Ik Lee ; Jeong Ho Hong ; Park, Hyungjong ; Hyeon Chang Kim ; Yo Han Jung ; Tae Jin Song ; Lee, Kyung-Yul ; Dong Hoon Shin ; Jong Yun Lee ; Byung Moon Kim ; Ji Hoe Heo ; Kwon Duk Seo ; Heo, JoonNyung |
Link: | |
Zeitschrift: | Stroke, Jg. 52 (2021-06-01), S. 2026-2034 |
Veröffentlichung: | Ovid Technologies (Wolters Kluwer Health), 2021 |
Medientyp: | unknown |
ISSN: | 1524-4628 (print) ; 0039-2499 (print) |
DOI: | 10.1161/strokeaha.120.032380 |
Schlagwort: |
|
Sonstiges: |
|