Outcome of ABO Blood Type-Incompatible Living-Related Donor Kidney Transplantation Under a Contemporary Immunosuppression Strategy in Japan
In: Transplantation proceedings, Jg. 52 (2019-12-28), Heft 6
Online
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Zugriff:
Background Because of the serious donor shortage in Japan, there is an increasing need for ABO blood type–incompatible kidney transplantation (ABOi-KT) in living-related donor kidney transplantation. We evaluated the outcomes of ABOi-KT performed at our hospitals using a contemporary immunosuppression strategy with low-dose rituximab. Patients and Methods Between June 2006 and April 2019, 107 patients underwent living-related donor kidney transplantation at our hospitals. The patients were divided into ABO-compatible (ABOc) and ABOi groups. The basic immunosuppression regimen differed between the 2 groups in the use of low-dose rituximab and therapeutic apheresis in the ABOi group. We compared graft survival, patient survival, rejection, viral infection, and posttransplant renal function between the 2 groups. Results Of 107 recipients, 37 (35%) underwent ABOi-KT. The 5-year graft survival rates in the ABOc and ABOi group were 91% and 100%, respectively. The Kaplan-Meier analyses showed no difference in graft survival (P = .168) or patient survival (P = .873) between the groups. Biopsy-proven rejection in the ABOc and ABOi groups was observed in 13 (19%) and 7 (19%) patients, respectively (P = .965), and viral infection was observed in 21 (30%) and 10 (27%) patients (P = .747), respectively. Renal function by estimated glomerular filtration rate from 1 week to 5 years after transplantation was similar in both groups. Conclusions The outcomes of ABOi-KT with low-dose rituximab were comparable with those of ABOc-KT at our hospitals. ABOi-KT with proper immunosuppression may be an option to help resolve the severe donor shortage in Japan.
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Outcome of ABO Blood Type-Incompatible Living-Related Donor Kidney Transplantation Under a Contemporary Immunosuppression Strategy in Japan
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Autor/in / Beteiligte Person: | Fujita, Takeshi ; Hamaya, Tomoko ; Togashi, Kyo ; Ohyama, Chikara ; Yamamoto, Hayato ; Murakami, Reiichi ; Yoneyama, Tohru ; Hatakeyama, Shingo ; Narumi, Shunji ; Hamano, Itsuto ; Tomita, Hirofumi ; Hashimoto, Yasuhiro ; Yoneyama, Takahiro ; Suzuki, Yuichiro |
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Zeitschrift: | Transplantation proceedings, Jg. 52 (2019-12-28), Heft 6 |
Veröffentlichung: | 2019 |
Medientyp: | unknown |
ISSN: | 1873-2623 (print) |
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