A decade of neonatal sepsis caused by gram-negative bacilli—a retrospective matched cohort study
In: European Journal of Clinical Microbiology & Infectious Diseases, Jg. 40 (2021-03-01), Heft 9, S. 1803-1813
Online
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Zugriff:
This study is to determine the incidence and outcome of neonatal gram-negative bacilli (GNB) sepsis in Stockholm, Sweden, and describe bacterial characteristics. This is a retrospective cohort study. All infants with GNB-sepsis between 2006 and 2016 were included and matched with two control groups, with suspected sepsis and uninfected neonates, respectively. Outcome was death before discharge, risk of death within 5 days after sepsis onset, and morbidity. The resistance pattern from all GNB was collected, and all available isolates were subjected to genome typing. All neonates with GNB-sepsis (n = 107) were included, and the cumulative GNB-sepsis incidence was 0.35/1000 live born. The in-hospital mortality was 30/107 (28%). GNB late-onset sepsis (LOS) was associated with an increase in mortality before discharge compared to uninfected controls (OR = 3.9; CI 1.6–9.4) but not versus suspected sepsis. The suspected LOS cases did not statistically differ significantly from uninfected controls. The case fatality rate (CFR) at 5 days was 5/33 (15%) in GNB early-onset sepsis (EOS) and 25/74 (34%) in GNB-LOS. The adjusted hazard for 5 days CFR was higher in GNB-LOS versus uninfected controls (HR = 3.7; CI 1.2–11.2), but no significant difference was seen in GNB-LOS versus suspected sepsis or in suspected sepsis versus controls. ESBL production was seen in 7/107 (6.5%) of the GNB isolates. GNB-LOS was associated with a higher 5 days CFR and in-hospital mortality compared to uninfected controls but not versus suspect sepsis. The incidence of both GNB-EOS and GNB-LOS was lower than previously reported from comparable high-income settings. The occurrence of antibiotic resistance was low. Supplementary Information The online version contains supplementary material available at 10.1007/s10096-021-04211-8.
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A decade of neonatal sepsis caused by gram-negative bacilli—a retrospective matched cohort study
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Autor/in / Beteiligte Person: | Giske, Christian G. ; Navér, Lars ; Iversen, Aina ; Ininbergs, Karolina ; Tidell, Annika ; Nordberg, V |
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Zeitschrift: | European Journal of Clinical Microbiology & Infectious Diseases, Jg. 40 (2021-03-01), Heft 9, S. 1803-1813 |
Veröffentlichung: | Springer Berlin Heidelberg, 2021 |
Medientyp: | unknown |
ISSN: | 1435-4373 (print) ; 0934-9723 (print) |
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