Aims Neurocognitive deficits in chronic alcoholic men are well documented. Impairments include memory, visual–spatial processing, problem solving and executive function. The cause of impairment could include direct effects of alcohol toxicity, pre‐existing cognitive deficits that predispose towards substance abuse, comorbid psychiatric disorders and abuse of substances other than alcohol. Cigarette smoking occurs at higher rates in alcoholism and has been linked to poor cognitive performance, yet the effects of smoking on cognitive function in alcoholism are often ignored. We examined whether chronic alcoholism and chronic smoking have effects on executive function. Methods Alcoholism and smoking were examined in a community‐recruited sample of alcoholic and non‐alcoholic men (n = 240) using standard neuropsychological and reaction‐time measures of executive function. Alcoholism was measured as the average level of alcoholism diagnoses across the study duration (12 years). Smoking was measured in pack‐years. Results Both alcoholism and smoking were correlated negatively with a composite executive function score. For component measures, alcoholism was correlated negatively with a broad range of measures, whereas smoking was correlated negatively with measures that emphasize response speed. In regression analyses, both smoking and alcoholism were significant predictors of executive function composite. However, when IQ is included in the regression analyses, alcoholism severity is no longer significant. Conclusions Both smoking and alcoholism were related to executive function. However, the effect of alcoholism was not independent of IQ, suggesting a generalized effect, perhaps affecting a wide range of cognitive abilities of which executive function is a component. On the other hand, the effect of smoking on measures relying on response speed were independent of IQ, suggesting a more specific processing speed deficit associated with chronic smoking.
Keywords: cigarette smoking; cognition; executive function; response inhibition; Alcoholism
Neurocognitive deficits in men with chronic alcohol use disorders (AUD) are well documented and include visual–spatial processing, problem solving, memory and cognitive proficiency [
Although AUD is known to have neuropsychological consequences linked with brain impairment, the exact mechanism is unclear [
For example, cigarette smoking occurs at a much higher rate in AUD than in the general population. Surprisingly, the negative effects of smoking on cognition have been ignored until recently [
EF is defined as the ability to maintain an appropriate mental set in order to fulfill a future goal [
Additionally, most studies of EF in AUD have focused upon neuropsychological tests where performance is based on several component processes. Other tests offer specific focus upon individual components; for example, the Stopping Task uses a reaction‐time procedure designed to isolate the ability to inhibit an ongoing behavioral response, an important component of EF [
To our knowledge, the Stopping Task has not been tested in AUD, but there is reason to suspect impairment. Children of alcoholic fathers had poorer Stopping Task reaction‐times [
In this paper, EF is examined in a community‐recruited sample of men with and without AUD. Executive function impairments in samples from treatment sites have been reported; the current results generalize those findings to a larger population using both traditional neuropsychological measures and reaction‐time measures. The effects of smoking on EF in AUD are novel.
Data were from 240 men who completed an executive functioning battery as part of wave 5 data collection in the Michigan Longitudinal Study (MLS) [
Data were collected in individual homes by trained project staff, blind to diagnostic status, as part of the regular data collection for the MLS. The assessment took 2 hours to complete. Home administration ensured privacy and freedom from distractions. A short questionnaire assessed if there were barriers to collecting valid data (e.g. lack of sleep, immediately prior use of alcohol, recreational or prescription drugs). If two or more alcoholic drinks were taken within the hour prior to testing, or the person appeared intoxicated or 'high', the assessment was rescheduled. Other than self‐report and the judgement of the examiner; no other drug screens were employed. Participants who smoked were allowed to smoke cigarettes prior to testing and during breaks. Breaks were taken on an as‐requested basis at the end of each test, thus most participants were not in a state of nicotine withdrawal; however, a formal test of nicotine withdrawal was not included.
The specific tests were selected to address our hypotheses with a combination of instruments having strong psychometric properties. The focus was EF, construed broadly as a multi‐faceted construct [
The Stroop Test [
The COWAT [
The WCST consists of four stimulus cards and 64 response cards that depict figures of varying forms, colors and numbers of figures. Participants are told to match each consecutive card from the deck with one of the four stimulus cards. The participant is told whether his/her response is correct or wrong, but is not told the sorting principle involved. The participant must match the sorting principle (color, form or number) for a specified number of responses before the sorting principle is changed. For this study we used the computer version of the instrument. Reported are the number of categories achieved and number of perseverative errors.
The PASAT measures verbal working memory, attention, concentration and speed of information processing. The test requires the participant to add randomized digits so that each is added to the digit immediately preceding it. The digits are presented at four rates of speed. A taped representation is used to provide precise control over the rate at which stimuli are presented. Reported are the total number of correct responses.
The TMT is a widely used measure of visual conceptual and visual‐motor tracking as well as set‐switching. TMT consists of two parts, with sequential circles containing ascending numbers (part A) and alternating numbers and letters (part B). Participants draw lines between the sequential circles, with the examiner pointing out errors to the participant as they occur. If an error occurs, the participant corrects the error and continues the task. Reported are the times taken to complete each part.
During this two‐alternative choice reaction‐time task, participants see an X or an O on a computer screen and respond rapidly with one of two keys. On some trials a tone sounds shortly after the X or O appears, indicating that participants should withhold a response. After two practice blocks of 32 trials each, four blocks of 64 trials are administered. The final three blocks are averaged unless data quality checks suggest otherwise [
Due to the nature of our sample, the assignment of participants to either control or alcoholic group was not always clear. For example, some participants met diagnostic criteria for AUD early in life, but not at the time of testing. To address diagnostic variation over time, we developed a continuous variable of alcohol severity. The alcoholism severity index was computed by averaging across T1 (baseline) to T5 (12 years). The severity at each wave was coded as: 0 for negative diagnosis; 1 for alcohol abuse; 2 for alcohol dependence without physical dependence; and 3 for alcohol dependence with physical dependence. The resulting index is a continuous scale ranging from 0 to 3.
A monthly drinking rate for each participant (see Table 1) was calculated based on the Drinking and Drug History Questionnaire (number of days each month where alcohol is consumed multiplied by the average number of drinks consumed per day on a day when alcohol is consumed over the past 6 months).
1 Demographics, drinking rate, smoking and other drug by alcoholism severity group.
Age 46.2 (6.1) 43.8 (5.1) 44.3 (4.8) 44.8 (4.7) Education 14.7 (2.3) 14.0 (2.8) 13.5 (2.3) 13.9 (2.3) IQ 110.8 (13.0) 105.6 (12.0) 100.8 (10.4) 104.3 (14.5) Depression 4.4 (4.9) 6.7 (7.0) 6.1 (6.2) 6.9 (7.4) ASPD 7% 12% 33% 35% ADHDsx 0.04 (0.14) 0.11 (0.25) 0.07 (0.17) 0.06 (0.15) Smoking (PkYrs) 5.6 (17.0) 10.8 (15.3) 11.9 (15.1) 19.4 (17.6) Other drug use 0.4 (1.5) 2.1 (4.4) 2.3 (3.4) 6.7 (7.9) Drinking rate months) 5.8 (11.6) 32.5 (59.3) 63.9 (111.5) 104.3 (92.6)
1 Group 1: severity = 0; group 2: 0 < severity ≤ 1; group 3: 1 < severity ≤ 2; group 4: 2 < severity ≤ 3; ASPD: antisocial personality disorder, percentage with diagnosis; ADHDsx: attention deficit hyperactivity disorder, symptom count percentage; IQ: intelligence quotient; PkYrs: pack‐years; other drug use: sum of reported use of drugs other than alcohol or nicotine over the past 3 years; drinking rate: over the past 6 months, the average number of alcoholic drinks normally consumed in a month; data are mean (standard deviation), unless otherwise not.
Rate of smoking was obtained from the Drinking and Drug History Questionnaire. At the time of testing, 41.5% reported regular smoking. A continuous variable, called 'pack‐years', was created by multiplying average daily use (in packs) by the number of years smoking (see Table 1). Daily use was estimated from self‐reported rate of smoking from study waves 1–5. Years of smoking was estimated from self‐reported age at smoking onset to current age. Among those who had ever smoked, average pack‐years were 20.17 years.
Use of drugs other than alcohol or cigarettes was obtained from the Drinking and Drug History Questionnaire. Participants were asked on how many occasions during the last 3 years they had used: marijuana, lysergic acid diethylamide (LSD), psychedelics other than LSD, cocaine, amphetamines, Quaaludes, barbiturates, tranquilizers, heroin, narcotics other than heroin or sniffed glue. Marijuana had the highest frequency of use, with 22.2% of the sample reporting any use, followed by cocaine (6.1%) and tranquilizers (5.9%). A composite variable of any drug use was computed by summing the frequency of use for each of the individual drug categories for each participant (see Table 1). For the total drug‐use score, 24.5% of the sample reported some use in the past 3 years.
Depression at the time of testing was measured by clinician ratings using the Hamilton Depression Scale [
ASPD was assessed via interview using the Diagnostic Interview Schedule—version IV (DIS‐IV) [
This measure was a simple count of all ADHD symptom questions on the DIS‐IV, divided by the maximum possible score of 18 symptoms.
The highest level of education achieved at the time of testing was calculated as years of education.
IQ, one of the most widely accepted and psychometrically well‐established indices of intellectual functioning [
Each variable was standardized (using the sample mean and standard deviation for each individual variable) and if necessary reverse‐coded. An EF composite variable was created by averaging each of the variables for each participant.
There were about 10% missing data across variables. Multiple imputation proposed by Rubin was adopted to deal with missing data [
We examined zero‐order correlations between smoking, alcoholism severity and EF; first with the composite variable and then, if significant, with the component measures. All probabilities are one‐tailed.
To test the relationship between alcoholism severity, smoking and EF, we conducted a series of linear regression analyses using SAS PROC REG on each of the five plausible data sets generated by SAS PROC MI. SAS PROC MIANALYZE was used to aggregate the five sets of results. We started with the executive‐function composite; if significant, we followed‐up with regression analyses using component measures. For each EF variable, we tested up to four different regression models. Predictors were entered simultaneously for each of the models.
Model 1 investigated whether alcoholism severity and smoking were independent predictors of EF by including both severity and smoking in the regression model. Note that this model was tested only if both smoking and alcoholism severity were correlated significantly with the particular EF measure.
Model 2 added education to model 1, as education was lower in the alcoholic group. Some differences associated with alcoholism could be due simply to lower education attainment rather than dysfunction caused by alcoholism. However, given the life‐style associated with alcoholism there may be fewer opportunities for education, and therefore lower education is part of the syndrome. To examine whether alcoholism causes brain dysfunction, education should be included to control for its effects. To examine the overall consequences of alcoholism, controlling for education may underestimate the total effect. Because this is a descriptive paper documenting executive function in a community‐based sample, we present our analyses both with and without education included as a predictor.
Model 3 added IQ to model 1. As with education, whether or not to include IQ as a factor can be argued in either direction. It is theoretically interesting to know whether effects of alcoholism or smoking on EF are separable from IQ. Thus, we present our regression analyses both with and without IQ included in the models.
Model 4 added the Hamilton current depression score to model 1, as higher scores on depression were related to lower performance on the EF composite score and to four of the individual measures.
Finally, we tested whether EF and IQ become more correlated with increasing alcoholism severity by creating two separate dummy variables based on severity. One variable coded diagnosis of abuse or higher as 1 (no diagnosis was coded as 0). The other variable coded diagnosis of dependence as 1 and abuse or no diagnosis as 0. These two variables were included in a regression model along with IQ and the interaction between IQ and the dummy variables to predict EF (composite).
Means for the demographic, psychiatric and drinking, smoking and drug use measures by the four alcoholism severity groups are presented in Table 1. To present the data in tabular form, we divided the participants into four groups: alcoholism severity equals zero, less than or equal to one, less than or equal to two, and less than or equal to three.
Diagnosis of ASPD was more common in the highest two alcoholism severity groups. Further analysis showed higher level of smoking (pack‐years) among those with an ASPD diagnosis [mean = 21.3, standard deviation (SD) = 19.0] than those without the diagnosis (mean = 8.2, SD = 15.6). This difference was significant, t
Correlations Alcoholism was correlated significantly with smoking (r = 0.255, P < 0.001), other drug use (r = 0.363, P < 0.001), education (r = −0.181, P < 0.01), IQ (r = −0.211, P < 0.01) and depression (r = 0.1095, P < 0.05), but not ADHD symptoms (r = 0.034). Smoking was correlated significantly with other drug use (r = 0.137, P < 0.05), education (r = −0.219, P < 0.001) and IQ (r = −0.195, P < 0.01), but not depression (r = 0.020) or ADHD symptoms (r = 0.072).
Table 2 shows the zero‐order correlations between the EF measures and alcoholism severity, monthly drinking rate, smoking and other drug use. Alcoholism severity and monthly drinking rate were correlated significantly, but only moderately (r = 0.467, P < 0.001). Alcoholism severity, smoking, education, depression and IQ were all correlated significantly with the EF composite score. For the individual EF scores, alcoholism severity was correlated moderately negatively with at least one measure from each of the tests, but monthly drinking rate was not correlated with any of the EF measures. Therefore, our subsequent analyses focused upon alcoholism severity rather than drinking rate. Smoking, on the other hand, showed consistent correlations with tests that emphasize response speed. Other drug use was not correlated with any EF measure except SS‐RT.
2 Correlations of alcoholism severity, drinking rate, smoking and other drugs with executive function measures.
0.243*** −0.015 −0.236*** −0.019 COWAT −0.115* 0.020 0.038 0.185 PASAT −0.221*** 0.003 −0.080 −0.051 STROOP‐w −0.143** 0.057 −0.162** −0.087 STROOP‐c −0.154** 0.032 −0.130* 0.006 STROOP‐cw −0.119* −0.032 −0.056 0.013 WCST‐pe −0.045 −0.025 −0.050 0.082 WCST‐cat −0.113* −0.089 −0.078 0.044 TMT‐A −0.195*** 0.030 −0.229*** −0.024 TMT‐B −0.095 0.006 −0.213*** 0.048 Go‐RT −0.181** −0.019 −0.262*** −0.070 Go‐RT var. −0.194*** −0.077 −0.254*** −0.059 SS‐RT −0.167** −0.018 −0.221*** −0.119*
2 PkYrs: pack‐years; COWAT: Controlled Oral Word Association Test; PASAT: Paced Auditory Serial Addition Task; STROOP‐w: Stroop Word Reading Test; STROOP‐c: Stroop Color Naming Test; STROOP‐cw: Stroop Color Word Interference Test; WCST‐pe: Wisconsin Card Sorting Test, perseverative errors; WCST‐cat: Wisconsin Card Sorting Test, categories achieved; TMT‐A: Trail Making Test A; TMT‐B: Trail Making Test B; Go‐RT: Stopping Task go trials reaction‐time; Go‐RT var.: Stopping Task go trial reaction‐time variability; SS‐RT: Stopping Task stopping reaction‐time. *P < 0.05; **P < 0.01; ***P < 0.001.
Table 3 shows the zero‐order correlations between the EF measures and education, depression and IQ, which were all correlated significantly with the EF composite score. Education was correlated positively with all the EF measures except Go‐RT and Go‐RT variability. Depression was correlated with the Stroop color‐word task, TMT‐A and ‐B and Go‐RT variability. IQ was correlated with all the EF measures.
3 Correlations of education, depression and IQ with executive function.
0.353*** −0.144** 0.590*** COWAT 0.318*** −0.056 0.554*** PASAT 0.408*** −0.076 0.468*** STROOP‐w 0.282*** −0.091 0.342*** STROOP‐c 0.199*** −0.066 0.321*** STROOP‐cw 0.217*** −0.113* 0.395*** WCST‐pe 0.219*** −0.073 0.302*** WCST‐cat 0.165** −0.037 0.203*** TMT‐A 0.120* −0.187** 0.374*** TMT‐B 0.244*** −0.120* 0.467*** Go‐RT 0.082 −0.061 0.156** Go‐RT var. 0.184** −0.108* 0.331*** SS‐RT 0.099 −0.044 0.294***
3 COWAT: Controlled Oral Word Association Test; PASAT: Paced Auditory Serial Addition Task; STROOP‐w: Stroop Word Reading Test; STROOP‐c: Stroop Color Naming Test; STROOP‐cw: Stroop Color Word Interference Test; WCST‐pe: Wisconsin Card Sorting Test, perseverative errors; WCST‐cat: Wisconsin Card Sorting Test, categories achieved; TMT‐A: Trail Making Test A; TMT‐B: Trail Making Test B; Go‐RT: Stopping Task go trials reaction‐time; Go‐RT var.: Stopping Task go trial reaction‐time variability; SS‐RT: Stopping Task stopping reaction‐time; IQ: intelligence quotient. *P < 0.05, **P < 0.01, ***P < 0.001.
Table 4 shows the standardized EF means for each of the alcohol severity groups. For most of the measures, the means show decreasing performance with increasing alcoholism severity.
4 Standardized means (standard deviations) for executive function measures by alcoholism severity group.
Composite 0.12 (0.57) 0.07 (0.56) −0.17 (0.60) −0.19 (0.67) COWAT 0.15 (0.95) −0.06 (0.96) −0.14 (0.93) −0.02 (1.19) PASAT 0.17 (0.97) 0.17 (1.10) −0.40 (0.96) −0.35 (0.93) STROOP‐w 0.11 (1.00) 0.09 (1.05) −0.15 (0.93) −0.17 (0.96) STROOP‐c 0.12 (0.96) 0.06 (1.03) −0.15 (0.98) −0.21 (1.11) STROOP‐cw 0.06 (1.00) 0.08 (1.06) −0.09 (0.94) −0.20 (0.89) WCST‐pe −0.06 (1.15) 0.15 (0.75) −0.03 (0.84) −0.09 (1.20) WCST‐cat 0.02 (0.97) 0.17 (0.81) −0.12 (1.08) −0.22 (1.25) TMT‐A 0.19 (1.02) 0.18 (0.81) −0.36 (1.14) −0.18 (0.99) TMT‐B 0.11 (1.16) 0.06 (0.90) −0.25 (0.81) −0.03 (0.97) Go‐RT 0.19 (0.90) −0.04 (1.00) −0.13 (1.09) −0.31 (1.00) Go‐RT var. 0.20 (0.94) −0.06 (1.04) −0.13 (1.09) −0.30 (0.89) SS‐RT 0.17 (0.94) 0.04 (0.92) −0.15 (1.02) −0.24 (1.16)
4 Group 1: severity = 0; group 2: 0 < severity ≤ 1; group 3: 1 < severity ≤ 2; group 4: 2 < severity ≤ 3; COWAT: Controlled Oral Word Association Test; PASAT: Paced Auditory Serial Addition Task; STROOP‐w: Stroop Word Reading Test; STROOP‐c: Stroop Color Naming Test; STROOP‐cw: Stroop Color Word Interference Test; WCST‐pe: Wisconsin Card Sorting Test, perseverative errors; WCST‐cat: Wisconsin Card Sorting Test, categories achieved; TMT‐A: Trail Making Test A; TMT‐B: Trail Making Test B; Go‐RT: Stopping Task go trials reaction‐time; Go‐RT var.: Stopping Task go trial reaction‐time variability; SS‐RT: Stopping Task stopping reaction‐time.
Table 5 shows the regression coefficients for the four models described above for each of the EF measures. The alcoholism × smoking interaction was not significant and was dropped from all models. It should also be noted that models were tested for each measure only if the predictors to be included in the model had a significant zero‐order correlation with that measure.
5 Regression models predicting executive function.
Composite Alc. severity −0.127*** (0.042) −0.095** (0.040) −0.047 (0.035) −0.119** (0.061) Smoking (PkYrs) −0.007** (0.002) −0.005* (0.002) −0.004* (0.002) −0.007** (0.002) Education – 0.069*** (0.015) – – IQ – – 0.027*** (0.002) Depression – – – −0.011* (0.006) COWAT Alc. severity – −0.081 (0.070) −0.011 (0.062) – Education – 0.114*** (0.027) – – IQ – – 0.044*** (0.006) – PASAT Alc. severity – −0.155* (0.072) −0.102 (0.068) – Education – 0.156*** (0.027) – – IQ – – 0.039*** (0.006) – STROOP‐w Alc. severity −0.123* (0.090) −0.085 (0.071) −0.049 (0.072) – Smoking (PkYrs) −0.008* (0.004) −0.005 (0.004) −0.005 (0.004) – Education – 0.103*** (0.026) – – IQ – – 0.026*** (0.005) – STROOP‐c Alc. severity −0.137* (0.072) −0.113 (0.072) −0.059 (0.070) – Smoking (PkYrs) −0.006 (0.004) −0.004 (0.004) −0.003 (0.002) – Education – 0.065** (0.027) – – IQ – – 0.028*** (0.005) – STROOP‐cw Alc. severity – −0.081 (0.070) −0.049 (0.012) −0.114 (0.074) Education – 0.083*** (0.027) – – IQ – – 0.032*** (0.005) – Depression – – – −0.014 (0.011) WCST‐cat Alc. severity – −0.077 (0.072) −0.057 (0.072) – Education – 0.071** (0.027) – – IQ – – 0.016*** (0.005) – TMT‐A Alc. severity −0.153* (0.074) −0.121* (0.074) −0.056 (0.071) −0.132* (0.074) Smoking (PkYrs) −0.011** (0.004) −0.010** (0.004) −0.008* (0.004) −0.011** (0.010) Education – 0.030 (0.027) – – IQ – – 0.029*** (0.005) – Depression – – – Go‐RT Alc. severity −0.140* (0.075) – −0.115 (0.079) – Smoking (PkYrs) −0.014*** (0.004) – −0.013*** (0.004) – IQ – – 0.009* (0.005) – Go‐RT var. Alc. severity −0.167** (0.073) −0.145* (0.075) −0.096 (0.074) −0.157*** (0.074) Smoking (PkYrs) −0.014*** (0.004) −0.013*** (0.004) −0.011** (0.004) −0.014*** (0.004) Education – 0.036 (0.027) – – IQ – – 0.023*** (0.005) – Depression – – – −0.013 (0.011) SS‐RT Alc. severity −0.123* (0.075) – −0.047 (0.082) Smoking (PkYrs) −0.011** (0.004) – −0.009** (0.004) IQ – – 0.017*** (0.005)
5 For each executive function measure, alcoholism severity and pack‐years were included only if they had a significant correlation with that variable. Alc.: alcoholism; IQ: intelligence quotient; PkYrs: pack‐years. *P < 0.05; **P < 0.01; ***P < 0.001. COWAT: Controlled Oral Word Association Test; PASAT: Paced Auditory Serial Addition Task; STROOP‐w: Stroop Word Reading Test; STROOP‐c: Stroop Color Naming Test; STROOP‐cw: Stroop Color Word Interference Test; WCST‐cat: Wisconsin Card Sorting Test, categories achieved; TMT‐A: Trail Making Test A; Go‐RT: Stopping Task go trials reaction‐time; Go‐RT var.: Stopping Task go trial reaction‐time variability; SS‐RT: Stopping Task stopping reaction‐time; SE: standard error.
For model 1, alcoholism severity and smoking remained significant predictors of the EF composite, Stroop word reading, TMT‐A, Go‐RT, Go‐RT variability and SS‐RT, indicating that for these measures alcoholism and smoking have independent effects. For Stroop color naming, smoking dropped out; for this measure alcoholism mediated the effect of smoking.
For model 2 (education), alcoholism severity and smoking remained significant predictors of the EF composite, TMT‐A and Go‐RT variability. Thus, even with education included, both smoking and alcoholism were significant predictors of general EF and for some measures with an emphasis on response speed. However, the effects of smoking and alcoholism severity were reduced to non‐significant levels for Stroop word reading and Stroop color naming. The effects of alcoholism severity were reduced to non‐significant levels for COWAT, Stroop color–word and WCST categories. Alcoholism severity remained a significant predictor of PASAT.
For model 3 (IQ), the effects of alcoholism severity drop to non‐significant levels for all measures, including the EF composite. On the other hand, smoking (pack‐years) remained a significant predictor for the composite, TMT‐A, Go‐RT, Go‐RT variability and SS‐RT. Thus, even with IQ included, smoking continued to be a significant predictor of performance on tasks with an emphasis on response speed.
For model 4 (depression), alcoholism severity and smoking (pack‐years) remained significant predictors for the composite, TMT‐A and Go‐RT variability.
There was no evidence that EF and IQ became more correlated with increasing severity; the interaction terms between IQ and severity dummy variables were not significant (P > 0.06).
Because ASPD and ADHD are linked theoretically and empirically to EF and because ASPD was related significantly to alcoholism severity and drinking rate, as well as smoking, we also conducted separate regression analyses using the EF composite to be sure that our results were not due to the neurocognitive effects of these psychiatric measures. In a regression model with ASPD diagnosis, alcoholism severity and smoking (pack‐years), ASPD was not significant [coeff. = −0.132, standard error (SE) = 0.110; t = −1.19, P = 0.23], while both alcoholism severity (coeff. = −0.118, SE = 0.045; t = −2.64, P < 0.009) and smoking (pack‐years) (coeff. = −0.006, SE = 0.002; t = −2.30, P < 0.023) remained significant. In a similar model with ADHD symptoms, ADHD was not significant (coeff. = −0.269, SE = 0.222; t = −1.22, P = 0.223), while both alcoholism severity (coeff. = −0.128, SE = 0.046; t = −2.79, P < 0.006) and smoking (pack‐years) (coeff. = −0.007, SE = 0.003; t = −2.58. P < 0.011) remained significant.
This study follows‐up previous work to attempt to isolate associations of alcoholism and smoking with higher‐order cognitive abilities. Several interesting results emerged. To begin, among a community‐recruited sample of alcoholic men and controls a broad range of EF measures were correlated significantly with alcoholism severity. This extends the results of previous studies with samples recruited from treatment sites, where it is expected that the average severity of alcoholism is higher than our sample. The present data show lower performance in the precise way one would expect, given neuropsychological risk from alcohol use. These participants, while not impaired clinically, are not performing at the level of a carefully neighborhood‐matched non‐alcoholic group. Furthermore, our results were not explained by levels of ASPD or ADHD covarying with alcoholism severity and smoking. However, the effects of alcoholism severity on EF in our sample were not independent of IQ. Our results could indicate that the EF effects are subsumed under more general effects on overall intelligence.
The present results also show that smoking is an important variable for some measures of EF and has a pattern of effects that are distinct from AUD. In particular, smoking was correlated with measures that emphasize response speed. This adds to our previous work and shows that the effects of smoking are quite robust, because they remained significant even with education or IQ included in the regression models. Although we do not know the exact mechanism through which smoking is related to EF, one possibility is that, over time, smoking leads to poor cognitive proficiency. For example, chronic smoking may have damaging effects on the brain via several routes, including neurotoxic action, oxidative stress or by reducing blood flow. Risks for cardiovascular disease [
Previous research has suggested that smoking may mediate the effects of alcoholism on cognitive proficiency [
Finally, the effects of smoking and alcoholism severity on behavioral inhibition measured by the Stopping Task are new. The existing literature indicates EF deficits in alcoholics from traditional neuropsychological tests that measure more global aspects of EF. The present study demonstrates that a particular component of EF, the ability to inhibit a response, is also impaired in alcoholics and fits well with the view that drug abuse and addiction involve failures of response inhibition [
None.
This study was supported by NIDA grant R01 DA021032 to J.M. Glass and NIAAA grants R337 AA07065 and AA12217 to R.A. Zucker and J.T. Nigg.
By Jennifer M. Glass; Anne Buu; Kenneth M. Adams; Joel T. Nigg; Leon I. Puttler; Jennifer M. Jester and Robert A. Zucker
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