Procaine injections into MFB-LHA during septal and preoptic self-stimulation
In: Physiologybehavior, Jg. 6 (1971-06-01), Heft 6
Online
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Zugriff:
The possibility that regions of the medial forebrain bundle-lateral hypothalamic area (MFB-LHA) are involved in mediating the rewarding effect of electrical stimulation of the brain was examined by making unilateral injections of 2% procaine HCl (2μl) into this region during bar pressing for electrical stimulation in the septum or preoptic area. When the injection was made into the same side of the brain as the stimulating electrode, there was a strong suppression of self-stimulation rates as compared to the effect of isotonic saline injections. The effect occurred with injections anywhere along the entire length of the MFB-LHA. It was found that suppression was significantly less severe when procaine was injected into the MFB-LHA contralateral to the electrode. The stronger effect of procaine on the ipsilateral side suggests that suppression was not due to general disturbances of behavior. As a further control for nonspecific disturbances, similar injections were made in animals bar-pressing for food reward. The results showed that these injections generally suppressed bar-pressing only when made into those regions of the MFB-LHA which have been shown to be involved in feeding behavior. These results suggest that the entire MFB-LHA is a part of a system mediating the rewarding effect of electrical stimulation of the septum and preoptic area.
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Procaine injections into MFB-LHA during septal and preoptic self-stimulation
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Autor/in / Beteiligte Person: | Madryga, Frederick J. ; Albert, D.J. |
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Zeitschrift: | Physiologybehavior, Jg. 6 (1971-06-01), Heft 6 |
Veröffentlichung: | 1971 |
Medientyp: | unknown |
ISSN: | 0031-9384 (print) |
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