Economic burden of preemptive treatment of CMV infection after allogeneic stem cell transplantation: a retrospective study of 208 consecutive patients
In: BMC Infectious Diseases BMC Infectious Diseases, BioMed Central, 2017, Jg. 17 (2017), Heft 1, S. 1-8
Online
unknown
Zugriff:
International audience; BACKGROUND: Cytomegalovirus (CMV) infection and disease (CMV episodes) are global concerns after allogeneic hematopoietic stem cell transplantation (HSCT). They affect survival, both by direct and indirect effects. Due to safety issues of current anti-CMV antivirals, long-term CMV prophylaxis is poorly tolerated and the most common strategy to decrease the incidence of CMV disease is preemptive. New, less toxic, molecules are currently being assessed for CMV prophylaxis which should replace or considerably decrease the preemptive approach. The aim of this study was to assess the economic burden of CMV episodes after HSCT with a preemptive approach.METHODS: We analyzed data from 208 consecutive adults transplanted in our institution, between 2008 and 2013. Hospital resource utilization was retrieved via the linked hospital admissions and Diagnostic Related Groups for the period of conditioning to 12 months after transplant.RESULTS: CMV episodes occurred in 70 patients (34%) over the first 12 months following HSCT, after a mean of 75 days (median: 46 (7-334)). The mean total length of stay was significantly associated with the occurrence of a CMV episode (113.9 vs. 87.5 days, p = 0.0002) but was associated neither with the pre-transplant CMV serology of donors/recipients nor with survival. The mean cost of transplant was €104,016 (SD = €37,281) after 12 months. Bivariate and multivariate analyses indicated that the occurrence of >1 CMV episode increased the costs of allogeneic HSCT by 25-30% (p
Titel: |
Economic burden of preemptive treatment of CMV infection after allogeneic stem cell transplantation: a retrospective study of 208 consecutive patients
|
---|---|
Autor/in / Beteiligte Person: | Beckerich, Florence ; Toma, Andrea ; Robin, Christine ; Maury, Sébastien ; Cordonnier, Catherine ; Thillard, Julien ; Hemery, François ; Rodriguez, Christophe ; Redjoul, Rabah ; Durand-Zaleski, Isabelle ; Pautas, Cécile ; Cabanne, Ludovic ; Dindorf, Christel ; CHU Henri Mondor ; Université Paris-Est Créteil Val-de-Marne - Faculté de médecine (UPEC Médecine) ; Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12) ; Epidémiologie Clinique et Evaluation Economique Appliquées aux Populations Vulnérables (ECEVE (U1123 / UMR_S_1123)) ; Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AP-HP Hôpital universitaire Robert-Debré [Paris] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP) ; Institut Mondor de Recherche Biomédicale (IMRB) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12) ; Service de santé publique [Mondor] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12) ; Bodescot, Myriam |
Link: | |
Zeitschrift: | BMC Infectious Diseases BMC Infectious Diseases, BioMed Central, 2017, Jg. 17 (2017), Heft 1, S. 1-8 |
Veröffentlichung: | 2017 |
Medientyp: | unknown |
ISSN: | 1471-2334 (print) |
Schlagwort: |
|
Sonstiges: |
|