Kidney injury molecule-1 expression in transplant biopsies is a sensitive measure of cell injury
In: Kidney International, Jg. 73 (2008-03-01), Heft 5, S. 608-614
Online
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Zugriff:
Kidney injury molecule-1 (KIM-1) is a specific histological biomarker for diagnosing early tubular injury on renal biopsies. In this study, KIM-1 expression was quantitated in renal transplant biopsies by immunohistochemistry and correlated with renal function. None of the 25 protocol biopsies showed detectable tubular injury on histologic examination, yet 28% had focal positive KIM-1 expression. Proximal tubule KIM-1 expression was present in all biopsies from patients with histological changes showing acute tubular damage and deterioration of kidney function. In this group, higher KIM-1 staining predicted a better outcome with improved blood urea nitrogen (BUN), serum creatinine, and estimated glomerular filtration rate (eGFR) over an ensuing 18 months. KIM-1 was expressed focally in affected tubules in 92% of kidney biopsies from patients with acute cellular rejection. By contrast, there was little positive staining for Ki-67, a cell proliferation marker, in any of the groups. KIM-1 expression significantly correlated with serum creatinine and BUN, and inversely with the eGFR on the biopsy day. Our study shows that KIM-1 staining sensitively and specifically identified proximal tubular injury and correlated with the degree of renal dysfunction. KIM-1 expression is more sensitive than histology for detecting early tubular injury, and its level of expression in transplant biopsies may indicate the potential for recovery of kidney function.
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Kidney injury molecule-1 expression in transplant biopsies is a sensitive measure of cell injury
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Autor/in / Beteiligte Person: | Han, Won K. ; Blasick, T. M. ; Bonventre, Joseph V. ; Potdar, S. ; Zhang, Ping L. ; Rothblum, Lawrence I. |
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Zeitschrift: | Kidney International, Jg. 73 (2008-03-01), Heft 5, S. 608-614 |
Veröffentlichung: | Elsevier BV, 2008 |
Medientyp: | unknown |
ISSN: | 0085-2538 (print) |
DOI: | 10.1038/sj.ki.5002697 |
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