Effects of Vigabatrin on Cognitive Function and Mood When Used as Add-on Therapy in Patients with Intractable Epilepsy
In: Epilepsia, Jg. 33 (1992), S. 128-134
Online
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Zugriff:
Cognitive function and mood of patients with epilepsy who received 2 g/day vigabatrin (GVG) in addition to their usual antiepileptic drugs (AEDs) was assessed on two occasions: before start of treatment (baseline) and 4 weeks after start of treatment. A battery of selected psychological tasks measuring attention, mental speed, motor speed, central cognitive processing, and perceptuomotor performance was used, along with standardized, objective mood assessments. A comparison group (n = 15) of patients receiving stable medication was also tested to evaluate practice effects of the psychometric tests. Administration of 2 g/day GVG significantly decreased response time on a test of central cognitive processing ability (arithmetic). No adverse effect was noted on any other test of cognitive function or mood.
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Effects of Vigabatrin on Cognitive Function and Mood When Used as Add-on Therapy in Patients with Intractable Epilepsy
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Autor/in / Beteiligte Person: | Duncan, John S. ; Trimble, Michael R. ; McGuire, Anna M. |
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Zeitschrift: | Epilepsia, Jg. 33 (1992), S. 128-134 |
Veröffentlichung: | Wiley, 1992 |
Medientyp: | unknown |
ISSN: | 1528-1167 (print) ; 0013-9580 (print) |
DOI: | 10.1111/j.1528-1157.1992.tb02295.x |
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