Local and Systemic Inflammation and Oxidative Stress After a Single Bout of Maximal Walking in Patients With Symptomatic Peripheral Artery Disease
In: Journal of Cardiovascular Nursing, Jg. 36 (2021-09-01), S. 498-506
Online
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Zugriff:
Objective: The aim of this study was to assess the effects of a single bout of maximal walking on blood and muscle nitric oxide (NO) bioavailability, oxidative stress, and inflammation in symptomatic peripheral artery disease (PAD) patients. Methods: A total of 35 men with symptomatic PAD performed a graded maximal exercise test on a treadmill (3.2 km/h, 2% increase in grade every 2 minutes). Plasma samples and gastrocnemius muscle biopsies were collected preexercise and postexercise for assessment of NO bioavailability (plasma NO and muscle, endothelial NO synthase), oxidative stress and antioxidant function (lipid peroxidation [LPO], catalase [CAT], and superoxide dismutase), and inflammation (interleukin-6, C-reactive protein, tumor necrosis factor-α, intercellular adhesion molecules, and vascular adhesion molecules). The effects of the walking exercise were assessed using paired t tests or Wilcoxon tests. Results: After maximal walking, plasma NO and LPO were unchanged (P > .05), plasma CAT decreased, and all blood inflammatory markers increased (all P ≤ .05). In the disease-affected skeletal muscle, endothelial NO synthase, CAT, LPO, and all inflammatory markers increased, whereas superoxide dismutase decreased (all P ≤ .05). Conclusion: In patients with symptomatic PAD, maximal exercise induces local and systemic impairments, which may play a key role in atherogenesis. Exercise strategies that avoid maximal effort may be important to reduce local and systemic damage and enhance clinical benefits.
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Local and Systemic Inflammation and Oxidative Stress After a Single Bout of Maximal Walking in Patients With Symptomatic Peripheral Artery Disease
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Autor/in / Beteiligte Person: | Marcel da Rocha Chehuen ; Leicht, Anthony S. ; Andrade-Lima, Aluísio ; Natan Daniel da Silva Junior ; Patricia Chakur Brum ; Edilamar Menezes de Oliveira ; Miyasato, Roberto ; Wolosker, Nelson ; Cláudia Lúcia de Moraes Forjaz ; Rodrigo Wagner Alves de Souza |
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Zeitschrift: | Journal of Cardiovascular Nursing, Jg. 36 (2021-09-01), S. 498-506 |
Veröffentlichung: | Ovid Technologies (Wolters Kluwer Health), 2021 |
Medientyp: | unknown |
ISSN: | 1550-5049 (print) ; 0889-4655 (print) |
DOI: | 10.1097/jcn.0000000000000686 |
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