NK Cell Patterns in Idiopathic Inflammatory Myopathies with Pulmonary Affection
In: Cells, Jg. 10 (2021-09-01), Heft 2551
Online
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Zugriff:
Background: Pulmonary affection (PA) is associated with a substantial increase in morbidity and mortality in patients with idiopathic inflammatory myopathies (IIM). However, the underlying immune mechanisms of PA remain enigmatic and prompt deeper immunological analyses. Importantly, the Janus-faced role of natural killer (NK) cells, capable of pro-inflammatory as well as regulatory effects, might be of interest for the pathophysiologic understanding of PA in IIM. Methods: To extend our understanding of immunological alterations in IIM patients with PA, we compared the signatures of NK cells in peripheral blood using multi-color flow cytometry in IIM patients with (n = 12, of which anti-synthetase syndrome = 8 and dermatomyositis = 4) or without PA (n = 12). Results: We did not observe any significant differences for B cells, CD4, and CD8 T cells, while total NK cell numbers in IIM patients with PA were reduced compared to non-PA patients. NK cell alterations were driven by a particular decrease of CD56dim NK cells, while CD56bright NK cells remained unchanged. Comparisons of the cell surface expression of a large panel of NK receptors revealed an increased mean fluorescence intensity of NKG2D+ on NK cells from patients with PA compared with non-PA patients, especially on the CD56dim subset. NKG2D+ and NKp46+ cell surface levels were associated with reduced vital capacity, serving as a surrogate marker for clinical severity of PA. Conclusion: Our data illustrate that PA in IIM is associated with alterations of the NK cell repertoire, suggesting a relevant contribution of NK cells in certain IIMs, which might pave the way for NK cell-targeted therapeutic approaches.
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NK Cell Patterns in Idiopathic Inflammatory Myopathies with Pulmonary Affection
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Autor/in / Beteiligte Person: | Tomaras, Stylianos ; Allenbach, Yves ; Pawlitzki, Marc ; Nelke, Christopher ; Räuber, Saskia ; Regner, Liesa ; Schänzer, Anne ; Benveniste, Olivier ; Feist, Eugen ; Stenzel, Werner ; Preuße, Corinna ; Hasseli, Rebecca ; Ruck, Tobias ; Wiendl, Heinz ; Rolfes, Leoni ; Meuth, Sven G. ; University Hospital Münster - Universitaetsklinikum Muenster [Germany] (UKM) ; University Hospital Düsseldorf ; Kerckhoff-Klinik ; Helios Department of Rheumatology, Sophie-v.-Boetticher-Straße 1, 39245 Gommern, Germany ; Justus-Liebig-Universität Gießen (JLU) ; Charité - UniversitätsMedizin = Charité - University Hospital [Berlin] ; Service de Département de médecine interne et immunologie clinique [CHU Pitié-Salpêtrière] (DMIIC) ; CHU Pitié-Salpêtrière [AP-HP] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU) ; Centre de recherche en Myologie – U974 SU-INSERM ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU) ; Service de médecine interne et d'immunologie clinique [CHU Pitié-Salpêtrière] ; Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP) ; Centre de Recherche en Myologie ; Justus-Liebig-Universität Gießen = Justus Liebig University (JLU) ; HAL-SU, Gestionnaire |
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Zeitschrift: | Cells, Jg. 10 (2021-09-01), Heft 2551 |
Veröffentlichung: | MDPI AG, 2021 |
Medientyp: | unknown |
ISSN: | 2073-4409 (print) |
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