Phenotype and molecular signature of CD8+ T cell subsets in T cell- mediated rejections after kidney transplantation
In: PLoS ONE, Jg. 15 (2020-06-01), Heft 6
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Zugriff:
We investigated the phenotype and molecular signatures of CD8+ T cell subsets in kidney-transplant recipients (KTRs) with biopsy-proven T cell-mediated rejection (TCMR). We included 121 KTRs and divided them into three groups according to the pathologic or clinical diagnosis: Normal biopsy control (NC)(n = 32), TCMR (n = 50), and long-term graft survival (LTGS)(n = 39). We used flowcytometry and microarray to analyze the phenotype and molecular signatures of CD8+ T cell subsets using peripheral blood from those patients and analyzed significant gene expressions according to CD8+ T cell subsets. We investigated whether the analysis of CD8+ T cell subsets is useful for predicting the development of TCMR. CCR7+CD8+ T cells significantly decreased, but CD28nullCD57+CD8+ T cells and CCR7-CD45RA+CD8+ T cells showed an increase in the TCMR group compared to other groups (p
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Phenotype and molecular signature of CD8+ T cell subsets in T cell- mediated rejections after kidney transplantation
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Autor/in / Beteiligte Person: | Kim, Chan-Duck ; Jung Woo Seo ; Eun Jeong Ko ; Seok, Junhee ; Bo Mi Kim ; Kyoung Woon Kim ; Lee, Sang-Ho ; Chul Woo Yang ; Byung Ha Chung ; Cho, Jang-Hee |
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Zeitschrift: | PLoS ONE, Jg. 15 (2020-06-01), Heft 6 |
Veröffentlichung: | Public Library of Science, 2020 |
Medientyp: | unknown |
ISSN: | 1932-6203 (print) |
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