Yos9, a control protein for misfolded glycosylated and non-glycosylated proteins in ERAD
In: FEBS Letters, Jg. 585 (2011-08-23), S. 3015-3019
Online
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Zugriff:
The endoplasmic reticulum (ER) is responsible for folding and delivery of secretory proteins to their site of action. One major modification proteins undergo in this organelle is N-glycosylation. Proteins that cannot fold properly will be directed to a process known as endoplasmic reticulum associated degradation (ERAD). Processing of N-glycans generates a signal for ERAD. The lectin Yos9 recognizes the N-glycan signal of misfolded proteins and acts as a gatekeeper for the delivery of these substrates to the cytoplasm for degradation. Presence of Yos9 accelerates degradation of the glycosylated model ERAD substrate CPY∗. Here we show that Yos9 has also a control function in degradation of the unglycosylated ERAD substrate CPY∗0000. It decelerates its degradation rate.
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Yos9, a control protein for misfolded glycosylated and non-glycosylated proteins in ERAD
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Autor/in / Beteiligte Person: | Wolf, Dieter H. ; Stolz, Alexandra ; Elena Martinez Benitez |
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Zeitschrift: | FEBS Letters, Jg. 585 (2011-08-23), S. 3015-3019 |
Veröffentlichung: | Wiley, 2011 |
Medientyp: | unknown |
ISSN: | 0014-5793 (print) |
DOI: | 10.1016/j.febslet.2011.08.021 |
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