Paclitaxel-eluting stents versus everolimus-eluting coronary stents in a diabetic population: two-year follow-up of the TUXEDO-India trial
In: EuroIntervention, Jg. 13 (2017-11-01), S. 1194-1201
Online
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Zugriff:
Aims The aim of this study was to report whether the superiority of the everolimus-eluting stent (EES) vs. the paclitaxel-eluting stent (PES) at one-year follow-up in the Taxus Element versus Xience Prime in a Diabetic Population (TUXEDO)-India trial was sustained at longer-term follow-up. Methods and results One thousand eight hundred and thirty (1,830) patients with diabetes mellitus and coronary artery disease were randomised to EES vs. PES. Follow-up data up to two years were available in 1,701 (92.9%) patients. The primary endpoint was target vessel failure (TVF), defined as the composite of cardiac death, target vessel myocardial infarction (TV-MI), or ischaemia-driven target vessel revascularisation (TVR). Treatment with EES had a lower two-year rate of TVF (4.3% vs. 6.6%, p=0.03). Of the secondary endpoints, EES significantly reduced any MI (1.6% vs. 3.5%, p=0.01), TV-MI (0.7% vs. 3.1%, p=0.0001), ST (0.4% vs. 2.2%, p=0.001), cardiac death or target vessel MI (2.9% vs. 4.8%, p=0.04) and TLR (1.9% vs. 3.7%, p=0.02), compared with PES. Between one year and two years, no significant differences in the clinical outcomes were observed (pinteraction >0.05). Conclusions In this adequately powered trial, the benefits of EES vs. PES in a diabetic population seen at one year were maintained at two years.
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Paclitaxel-eluting stents versus everolimus-eluting coronary stents in a diabetic population: two-year follow-up of the TUXEDO-India trial
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Autor/in / Beteiligte Person: | Arambam, Priyadarshini ; Pinto, Brian ; Gurpreet Singh Wander ; Bangalore, Sripal ; Jagtap, Prashant ; Sathe, Shireesh ; Goel, Praveen K. ; Bhagwat, Ajit ; Kaul, Upendra |
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Zeitschrift: | EuroIntervention, Jg. 13 (2017-11-01), S. 1194-1201 |
Veröffentlichung: | Europa Digital & Publishing, 2017 |
Medientyp: | unknown |
ISSN: | 1774-024X (print) |
DOI: | 10.4244/eij-d-17-00333 |
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