Platelet production and destruction in liver cirrhosis
2011
Online
unknown
Zugriff:
BACKGROUND & AIMS: Thrombocytopenia is common in liver cirrhosis (LC) but the mechanisms are not fully understood. The purpose of our work was to evaluate platelet kinetics in LC with different etiologies by examining platelet production and destruction. METHODS: Ninety-one consecutive LC patients (36 HCV, 49 alcoholics, 15 HBV) were enrolled. As controls, 25 subjects with idiopathic thrombocytopenic purpura, 10 subjects with aplastic anemia, and 40 healthy blood donors were studied. Plasma thrombopoietin (TPO) was measured by ELISA. Reticulated platelets (RP) were determined using the Thiazole Orange method. Plasma glycocalicin (GC) was measured using monoclonal antibodies. Platelet associated and serum antiplatelet antibodies were detected by flow cytometry. B-cell monoclonality in PBMC was assessed by immunoglobulin fingerprinting. RESULTS: Serum TPO was significantly lower in LC (29.9±18.1 pg/ml) compared to controls (82.3±47.6 pg/ml). The GC levels were higher in LC (any etiology) than in healthy cases. Conversely, the absolute levels of RP were lower in LC (any etiology) than in healthy controls. The platelet-associated and serum anti-platelet antibodies were higher in HCV+ LC compared to healthy subjects (p
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Platelet production and destruction in liver cirrhosis
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Autor/in / Beteiligte Person: | Comar, Consuelo ; Uxa, Laura ; Zorat, Francesca ; Bonetto, Stefania ; Turchetto, Stefano ; Vincenzo De Angelis ; Pradella, P. ; Pozzato, Gabriele ; Pradella, P ; Bonetto, S ; Turchetto, S ; Uxa, L ; Comar, C ; Zorat, F ; De Angelis, V |
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Veröffentlichung: | 2011 |
Medientyp: | unknown |
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