Carbamazepine, but not valproate, displays pharmacoresistance in lamotrigine-resistant amygdala kindled rats
In: Epilepsy Research, Jg. 104 (2013-03-01), S. 26-34
Online
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Zugriff:
The voltage gated sodium channel (VGSC) blocker lamotrigine (LTG), when administered during kindling acquisition, leads to the development of resistance to LTG. The present study aimed to assess whether LTG-resistant amygdala-kindled rats display subsequent resistance to the VGSC blocker carbamazepine (CBZ) and the broad-spectrum antiepileptic drug (AED) sodium valproate (VPA). Two groups of male Sprague Dawley rats received either 0.5% methylcellulose (MC) or LTG (5mg/kg, i.p.) one hour before each amygdala kindling stimulation. Treatments were stopped once both the groups were fully kindled. Two days later, both groups were challenged with a higher dose of LTG (15 mg/kg, i.p.) to verify LTG-resistance in the experimental group (i.e., LTG-pretreated rats). The efficacy of CBZ and VPA was then evaluated in both groups. A higher dose of LTG blocked fully kindled seizures in the vehicle-treated rats but not seizures in the LTG-treated group. The mean seizure score, of the control group (1.2 ± 0.3) was significantly lower (p
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Carbamazepine, but not valproate, displays pharmacoresistance in lamotrigine-resistant amygdala kindled rats
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Autor/in / Beteiligte Person: | H. Steve White ; Srivastava, Ajay K. |
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Zeitschrift: | Epilepsy Research, Jg. 104 (2013-03-01), S. 26-34 |
Veröffentlichung: | Elsevier BV, 2013 |
Medientyp: | unknown |
ISSN: | 0920-1211 (print) |
DOI: | 10.1016/j.eplepsyres.2012.10.003 |
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