The MAP30 protein from bitter gourd (Momordica charantia) seeds promotes apoptosis in liver cancer cells in vitro and in vivo
In: Cancer Letters, Jg. 324 (2012-11-01), S. 66-74
Online
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Zugriff:
Human hepatocellular carcinoma Hep G2 cells and Hep G2-bearing mice were used as in vitro and in vivo models to assess the efficacy and safety of MAP30, a natural component from Momordica charantia, as an anticancer agent against liver cancer. Molecular studies disclosed the contribution of both caspase-8 regulated extrinsic and caspase-9 regulated intrinsic caspase cascades in MAP30-induced cell apoptosis. The antitumor potential was also effective in Hep G2-bearing nude mice. Since bitter gourd is a staple in many Asian countries, MAP30 would serve as a novel and relatively safe agent for prophylaxis and treatment of liver cancer.
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The MAP30 protein from bitter gourd (Momordica charantia) seeds promotes apoptosis in liver cancer cells in vitro and in vivo
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Autor/in / Beteiligte Person: | Tzi Bun Ng ; Wong, John ; Chris Zhiyi Zhang ; Evandro Fei Fang ; Shen, Jiayun ; Li, Chuanhao |
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Zeitschrift: | Cancer Letters, Jg. 324 (2012-11-01), S. 66-74 |
Veröffentlichung: | Elsevier BV, 2012 |
Medientyp: | unknown |
ISSN: | 0304-3835 (print) |
DOI: | 10.1016/j.canlet.2012.05.005 |
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