Biodegradable and Excretable 2D W1.33C i‐MXene with Vacancy Ordering for Theory‐Oriented Cancer Nanotheranostics in Near‐Infrared Biowindow
In: Advanced Science, Jg. 8 (2021), Heft 24, S. n/a-n/a
Online
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Zugriff:
MXenes, a new class of two-dimensional (2D) nanomaterials, have shown enormous potential for biological applications. Notably, the development of 2D MXenes in nanomedicine is still in its infancy. Herein, a distinct W1.33 C i-MXene with multiple theranostic functionalities, fast biodegradation, and satisfactory biocompatibility is explored. By designing a parent bulk laminate in-plane ordered (W2/3 Y1/3 )2 AlC ceramic and optionally etching aluminum (Al) and yttrium (Y) elements, 2D W1.33 C i-MXene nanosheets with ordered divacancies are efficiently fabricated. Especially, theoretical simulations reveal that W1.33 C i-MXene possesses a strong predominance of near-infrared (NIR) absorbance. The constructed ultrathin W1.33 C nanosheets feature excellent photothermal-conversion effectiveness (32.5% at NIR I and 49.3% at NIR II) with desirable biocompatibility and fast degradation in normal tissue rather than in tumor tissue. Importantly, the multimodal-imaging properties and photothermal-ablation performance of W1.33 C-BSA nanosheets are systematically revealed and demonstrated both in vitro and in vivo. The underlying mechanism and regulation factors for the W1.33 C-BSA nanosheets-induced hyperthermia ablation are also revealed by transcriptome and proteome sequencing. This work offers a paradigm that i-MXenes achieve the tailoring biomedical applications through composition and structure design on the atomic scale.
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Biodegradable and Excretable 2D W1.33C i‐MXene with Vacancy Ordering for Theory‐Oriented Cancer Nanotheranostics in Near‐Infrared Biowindow
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Autor/in / Beteiligte Person: | Du, Dou ; Zhou, Bangguo ; Xu, Hui-Xiong ; Yin, Haohao ; Feng, Wei ; Sun, Li-Ping ; Li, Xiao-Long ; Pu, Yinying ; Dong, Caihong ; Chen, Yu ; Han, Xiaoxia |
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Zeitschrift: | Advanced Science, Jg. 8 (2021), Heft 24, S. n/a-n/a |
Veröffentlichung: | Wiley, 2021 |
Medientyp: | unknown |
ISSN: | 2198-3844 (print) |
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