Correlation analysis of expression of CC and CXC chemokines in children with autism spectrum disorder
In: Medicine, Jg. 100 (2021-06-18), S. e26391
Online
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Zugriff:
To investigate the relationship between the expression of CC and CXC chemokines and autism spectrum disorder (ASD). A total of 62 children with ASD (ASD group) and 60 gender- and age-matched normal children (control group) admitted to our hospital from January 2019 to January 2020 were included in the study. Monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein-1α (MIP-1α), macrophage inflammatory protein-1β (MIP-1β), regulated upon activation, normal T-cell expressed and secreted (RANTES), interleukin-8 (IL-8), monokine induced by interferon (IFN)-γ (MIG), and purified human interferon-γ-induced protein-10 (IP-10) were detected in the ASD group. The correlation between the above indexes and the severity of the ASD group was analyzed. Significantly increased MCP-1 levels (P .05). Children in the ASD group showed significantly decreased IP-10 levels (P .05). MCP-1 level was positively related to the Module 1 scores of Autism Diagnostic Observation Schedule-second edition (ADOS-2), whereas the levels of Childhood Autism Rating Scale MIP-1α, MIP-1β, IL-8, IP-10, and MIG were negatively correlated with the ADOS-2 Module 1 scores (P .05). The levels of CC chemokines (MCP-1, MIP-1α, MIP-1β, and RANTES) and CXC chemokines (IL-8, IP-10, and MIG) are positively correlated with the pathogenesis of ASD. Inflammation is an important contributing factor to ASD.
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Correlation analysis of expression of CC and CXC chemokines in children with autism spectrum disorder
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Autor/in / Beteiligte Person: | Peng, Xiaofei ; Tong, Tingting ; Xu, Min ; Peng, Guangyang ; Peng, Xiaofang ; Zhang, Xiuyun |
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Zeitschrift: | Medicine, Jg. 100 (2021-06-18), S. e26391 |
Veröffentlichung: | Ovid Technologies (Wolters Kluwer Health), 2021 |
Medientyp: | unknown |
ISSN: | 1536-5964 (print) ; 0025-7974 (print) |
DOI: | 10.1097/md.0000000000026391 |
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