Urinary tubular biomarkers as predictors of death in critically ill patients with COVID-19
In: Biomarkers in medicine, Jg. 16 (2022-05-10), Heft 9
Online
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Zugriff:
Aim: To evaluate the prediction capacity of urinary biomarkers for death in critically ill patients with COVID-19. Methods: This is a prospective study with critically ill patients due to COVID-19 infection. The urinary biomarkers NGAL, KIM-1, MCP-1 and nephrin were quantified on ICU admission. Results: There was 40% of death. Urinary nephrin and MCP-1 had no association with death. Tubular biomarkers (proteinuria, NGAL and KIM-1) were predictors of death and cut-off values of them for death were useful in stratify patients with worse prognosis. In a multivariate cox regression analysis, only NGAL remains associated with a two-mount survival chance. Conclusion: Kidney tubular biomarkers, mostly urinary NGAL, had useful capacity to predict death in critically ill COVID-19 patients.
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Urinary tubular biomarkers as predictors of death in critically ill patients with COVID-19
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| Autor/in / Beteiligte Person: | Gabriela F Bezerra ; Gdayllon C Meneses ; Polianna LMM Albuquerque ; Nicole C Lopes ; Ranieri SS Santos ; Juliana C da Silva ; Sandra MB Mota ; Rodrigo R Guimarães ; Fábio R Guimarães ; Álvaro R Guimarães ; Caio MC Adamian ; Paula R de Lima ; Izabel CJ Bandeira ; Márcia MP Dantas ; Geraldo BS Junior ; Reinaldo B Oriá ; Elizabeth F Daher ; Alice MC Martins |
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| Zeitschrift: | Biomarkers in medicine, Jg. 16 (2022-05-10), Heft 9 |
| Veröffentlichung: | 2022 |
| Medientyp: | unknown |
| ISSN: | 1752-0371 (print) |
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