Impact of the Synbiotics and Urate-Lowering Therapy on Gut Microbiota and Cytokine Profile in Patients with Chronic Gouty Arthritis
In: Journal of Medicine and Life, Jg. 13 (2020-10-01), S. 490-498
Online
unknown
Zugriff:
The main goal of our study is the impact evaluation of complex urate-lowering therapy with the synbiotic addition on fecal microbiota and cytokine profile in patients with primary gout. During our study, 130 men (mean age 55.5 ± 9.4 years) with gout (duration 7.7 ± 7.1 years) were examined. All patients were divided into two treatment groups. The main group (n = 68) was taking allopurinol at 300 mg per day dose and additionally a synbiotic. The comparison group (n = 62) received allopurinol monotherapy without synbiotic intake. The therapy duration was 3 months. Evaluation of therapy efficiency was marked by blood uric acid changes, cytokine levels, CRP and fecal microbiota condition. After treatment, stabilization of the gut microbiota parameters was observed, which was leading to normalization uricemia levels (40.3% vs. 21%, p
| Titel: |
Impact of the Synbiotics and Urate-Lowering Therapy on Gut Microbiota and Cytokine Profile in Patients with Chronic Gouty Arthritis
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| Autor/in / Beteiligte Person: | Oksana Mykhailivna Tarasenko ; Olena Myroslavivna Karmazina ; Valentyn Valentinovich Taranchuk ; Kondratiuk, V |
| Link: | |
| Zeitschrift: | Journal of Medicine and Life, Jg. 13 (2020-10-01), S. 490-498 |
| Veröffentlichung: | S.C. JURNALUL PENTRU MEDICINA SI VIATA S.R.L, 2020 |
| Medientyp: | unknown |
| ISSN: | 1844-3117 (print) ; 1844-122X (print) |
| DOI: | 10.25122/jml-2020-0065 |
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