Synthesis of Misoprostol, and Intramolecular Isomerization of A-Type Misoprostol into B-Type Misoprostol using 1, 8-Diazabicyclo [5.4.0] undec- 7-ene (DBU)
In: Current Organic Synthesis, Jg. 20 (2023-06-01), S. 484-490
Online
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Zugriff:
Objective: Misoprostol is a synthetic prostaglandin that is related structurally to naturally occurring prostaglandin (PG), and it has been acknowledged as an effective inhibitor of gastric acid secretion when administered intravenously. Methods: In the present study, the novel application of 1,8-Diazabicyclo[5.4.0]undec-7-ene, a cyclic unsaturated amine [DBU] for the conversion of A-type Misoprostol (A-MP) to B-type Misoprostol (B-MP) via intramolecular isomerization. Results: The chemical structures of A-MP and B-MP were confirmed using spectral analyses of 1H-NMR, 13C-NMR and Mass spectroscopy. Conclusion: The chemical structures of A-MP and B-MP were confirmed using spectral analyses of 1H-NMR, 13C-NMR and Mass spectroscopy.
| Titel: |
Synthesis of Misoprostol, and Intramolecular Isomerization of A-Type Misoprostol into B-Type Misoprostol using 1, 8-Diazabicyclo [5.4.0] undec- 7-ene (DBU)
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| Autor/in / Beteiligte Person: | Nagarjuna Reddy, Guttikonda ; Rama Mohana Reddy, Jaggavarapu ; Muvvala, Venkatanarayana ; Raja Reddy, Kamatham ; Akula, Nagarjuna ; Ravi Kumar, Cheedarala ; Ravikumar, Surepally |
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| Zeitschrift: | Current Organic Synthesis, Jg. 20 (2023-06-01), S. 484-490 |
| Veröffentlichung: | Bentham Science Publishers Ltd., 2023 |
| Medientyp: | unknown |
| ISSN: | 1570-1794 (print) |
| DOI: | 10.2174/1570179419666220831100708 |
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