Cholesterol-rich nanoemulsion (LDE) as a novel drug delivery system to diagnose, delineate, and treat human glioblastoma
In: Materials Science and Engineering: C, Jg. 123 (2021-04-01), S. 111984-111984
Online
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Zugriff:
We have prepared and characterized a cholesterol-rich nanoemulsion called LDE, a mimic of classic lipoprotein macromolecules, that can be applied as a new drug delivery system for aluminum phthalocyanine chloride (PcAlCl). The LDE containing PcAlCl system prepared herein had mean size and zeta potential of 127 nm and −29 mV, respectively, and encapsulation rate efficiency was 81%, and stability of 17 months. Compared to classical liposomes, LDE was more efficient, especially in brain diseases like glioblastoma (GBM), as revealed by tests on the U-87 MG cell line. The LDEPc formulation did not display dark cytotoxicity, as expected. The best light dose for LDEPc was 1.0 J·cm−2: its activity was 55% higher than PcAlCl in a compatible organic medium. In the U-87 MG cells, apoptosis was the preferential pathway activated by PDT. These results strongly support the use of LDE as a new theranostic system.
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Cholesterol-rich nanoemulsion (LDE) as a novel drug delivery system to diagnose, delineate, and treat human glioblastoma
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Autor/in / Beteiligte Person: | Cristiano Ceron Jayme ; Emanoel P.O. Silva ; Leonardo Pereira Franchi ; Henrique Luis Piva ; Antonio Claudio Tedesco |
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Zeitschrift: | Materials Science and Engineering: C, Jg. 123 (2021-04-01), S. 111984-111984 |
Veröffentlichung: | Elsevier BV, 2021 |
Medientyp: | unknown |
ISSN: | 0928-4931 (print) |
DOI: | 10.1016/j.msec.2021.111984 |
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