Netrin Synergizes Signaling and Adhesion through DCC
In: Trends in Biochemical Sciences, Jg. 45 (2020), S. 6-12
Online
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Zugriff:
Netrin is a prototypical axon guidance cue. Structural studies have revealed how netrin interacts with the deleted in colorectal cancer (DCC) receptor, other receptors, and co-factors for signaling. Recently, genetic studies suggested that netrin is involved in neuronal haptotaxis, which requires a reversible adhesion process. Structural data indicate that netrin can also mediate trans-adhesion between apposing cells decorated with its receptors on the condition that the auxiliary guidance cue draxin is present. Here, we propose that netrin is involved in conditional adhesion, a reversible and localized process that can contribute to cell adhesion and migration. We suggest that netrin-mediated adhesion and signaling are linked, and that local environmental factors in the ventricular zone, the floor plate, or other tissues coordinate its function.
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Netrin Synergizes Signaling and Adhesion through DCC
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Autor/in / Beteiligte Person: | Zhang, Yan ; Wang, Jia-huai ; Meijers, Rob ; Smock, Robert G. |
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Zeitschrift: | Trends in Biochemical Sciences, Jg. 45 (2020), S. 6-12 |
Veröffentlichung: | Elsevier BV, 2020 |
Medientyp: | unknown |
ISSN: | 0968-0004 (print) |
DOI: | 10.1016/j.tibs.2019.10.005 |
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