Effect of renal denervation on coronary flow reserve in patients with resistant hypertension
In: Clinical Physiology and Functional Imaging, Jg. 39 (2018-05-14), S. 15-21
Online
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Zugriff:
Renal denervation (RDN) is a potential modality in the treatment of patients with resistant hypertension (RH) and has shown beneficial effect on a variety of cardiovascular surrogate markers. Coronary flow reserve, as assessed by transthoracic Doppler echocardiography (TDE-CFR) is impaired in patients with hypertension and is an independent predictor of cardiac morbidity. However, data on the effect of RDN on TDE-CFR are scarce. The main objective of this study was to assess the effect of RDN on TDE-CFR. Twenty-six consecutive patients with RH (9 female and 17 male; mean age 62 ± 8 years; mean number of antihypertensive drugs 4·2 ± 1·6) underwent bilateral RDN. CFR was assessed at baseline and 6 months after intervention. Mean flow velocity was measured in the left anterior descending artery by transthoracic Doppler echocardiography at baseline and during adenosine infusion (TDE-CFR). Systolic office blood pressure was reduced at follow-up (174 ± 24 versus 162 ± 27 mmHG; P = 0·01). Mean systolic ambulatory blood pressure decreased from 151 ± 21 to 147 ± 18 (P = 0·17). TDE-CFR remained unchanged 6 months after intervention (2·7 ± 0·6 versus 2·7 ± 0·7; P = 0·67). In conclusion, renal denervation was not associated with any changes in regard to coronary flow reserve at 6-month follow-up.
Titel: |
Effect of renal denervation on coronary flow reserve in patients with resistant hypertension
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Autor/in / Beteiligte Person: | Ljungman, Charlotta ; Völz, Sebastian ; Andersson, Bert ; Svedlund, Sara ; Gan, Li-Ming ; Rundqvist, Bengt |
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Zeitschrift: | Clinical Physiology and Functional Imaging, Jg. 39 (2018-05-14), S. 15-21 |
Veröffentlichung: | Wiley, 2018 |
Medientyp: | unknown |
ISSN: | 1475-0961 (print) |
DOI: | 10.1111/cpf.12523 |
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