A genome-wide association study of diabetic kidney disease in subjects with type 2 diabetes
In: Scopus-Elsevier Finnish Diabetic Nephropathy Study (FinnDiane), Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Research Group (Daniel Witte; member), Ahluwalia, T S, Linneberg, A, Christensen, C & Brandslund, I 2018, ' A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes ', Diabetes, vol. 67, no. 7, pp. 1414-1427 https://doi.org/10.2337/db17-0914 Diabetes 67, 1414-1427 (2018) Diabetes van Zuydam, N R, Ahlqvist, E, Sandholm, N, Deshmukh, H, Rayner, N W, Abdalla, M, Ladenvall, C, Ziemek, D, Fauman, E, Robertson, N R, McKeigue, P M, Valo, E, Forsblom, C, Harjutsalo, V, Perna, A, Rurali, E, Marcovecchio, M L, Igo, R P, Salem, R M, Perico, N, Lajer, M, Käräjämäki, A, Imamura, M, Kubo, M, Takahashi, A, Sim, X, Liu, J, van Dam, R M, Jiang, G, Tam, C H T, Luk, A O Y, Lee, H M, Lim, C K P, Szeto, C C, So, W Y, Chan, J C N, Ang, S F, Dorajoo, R, Wang, L, Hua Clara, T S, McKnight, A-J, Duffy, S, Pezzolesi, M G, Consortium, G, Marre, M, Gyorgy, B, Hadjadj, S, Hiraki, L T, Ahluwalia, T S, Maxwell, A P & FINNDIANE Study centres 2018, ' A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes ', Diabetes, vol. 67, no. 7, pp. 1414-1427 . https://doi.org/10.2337/db17-0914 van Zuydam, N R, Ahlqvist, E, Sandholm, N, Deshmukh, H, Rayner, N W, Abdalla, M, Ladenvall, C, Ziemek, D, Fauman, E, Robertson, N R, McKeigue, P M, Valo, E, Forsblom, C, Harjutsalo, V, Perna, A, Rurali, E, Marcovecchio, M L, Igo, R P, Salem, R M, Perico, N, Lajer, M, Käräjämäki, A, Imamura, M, Kubo, M, Takahashi, A, Sim, X, Liu, J, van Dam, R M, Jiang, G, Tam, C H T, Luk, A O Y, Lee, H M, Lim, C K P, Szeto, C C, So, W Y, Chan, J C N, Ang, S F, Dorajoo, R, Wang, L, Hua Clara, T S, McKnight, A-J, Duffy, S, Pezzolesi, M G, Consortium, G, Marre, M, Gyorgy, B, Hadjadj, S, Hiraki, L T & Ahluwalia, T S & Colhoun, H M 2018, ' A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes ', Diabetes . https://doi.org/10.2337/db17-0914 Finnish Diabetic Nephropathy Study (FinnDiane) 2018, ' A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes ', Diabetes, vol. 67, no. 7, pp. 1414-1427 . https://doi.org/10.2337/db17-0914; S. 1414-1427
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Zugriff:
Identification of sequence variants robustly associated with predisposition to diabetic kidney disease (DKD) has the potential to provide insights into the pathophysiological mechanisms responsible. We conducted a genome-wide association study (GWAS) of DKD in type 2 diabetes (T2D) using eight complementary dichotomous and quantitative DKD phenotypes: the principal dichotomous analysis involved 5,717 T2D subjects, 3,345 with DKD. Promising association signals were evaluated in up to 26,827 subjects with T2D (12,710 with DKD). A combined T1D+T2D GWAS was performed using complementary data available for subjects with T1D, which, with replication samples, involved up to 40,340 subjects with diabetes (18,582 with DKD). Analysis of specific DKD phenotypes identified a novel signal near GABRR1 (rs9942471, P = 4.5 × 10-8) associated with microalbuminuria in European T2D case subjects. However, no replication of this signal was observed in Asian subjects with T2D or in the equivalent T1D analysis. There was only limited support, in this substantially enlarged analysis, for association at previously reported DKD signals, except for those at UMOD and PRKAG2, both associated with estimated glomerular filtration rate. We conclude that, despite challenges in addressing phenotypic heterogeneity, access to increased sample sizes will continue to provide more robust inference regarding risk variant discovery for DKD. ASTAR (Agency for Sci., Tech. and Research, S’pore) NMRC (Natl Medical Research Council, S’pore)
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A genome-wide association study of diabetic kidney disease in subjects with type 2 diabetes
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| Autor/in / Beteiligte Person: | van Zuydam, Natalie R ; Ahlqvist, Emma ; Sandholm, Niina ; Deshmukh, Harshal ; Rayner, N William ; Abdalla, Moustafa ; Ladenvall, Claes ; Ziemek, Daniel ; Fauman, Eric ; Robertson, Neil R ; Mckeigue, Paul M ; Valo, Erkka ; Forsblom, Carol ; Harjutsalo, Valma ; Perna, Annalisa ; Rurali, Erica ; Marcovecchio, M Loredana ; Igo, Robert P ; Salem, Rany M ; Perico, Norberto ; Lajer, Maria ; Käräjämäki, Annemari ; Imamura, Minako ; Kubo, Michiaki ; Takahashi, Atsushi ; Sim, Xueling ; Liu, Jianjun ; van Dam, Rob M ; Jiang, Guozhi ; Tam, Claudia H T ; Luk, Andrea O Y ; Lee, Heung Man ; Lim, Cadmon K P ; Szeto, Cheuk Chun ; Wing Yee, So ; Chan, Juliana C N ; Ang, Su Fen ; Dorajoo, Rajkumar ; Wang, Ling ; Clara, Tan Si Hua ; Mcknight, Amy-Jayne ; Duffy, Seamus ; Pezzolesi, Marcus G ; Marre, Michel ; Gyorgy, Beata ; Hadjadj, Samy ; Hiraki ; Koivula, S ; Uggeldahl, T ; Forslund, T ; Halonen, A ; Koistinen, A ; Koskiaho, P ; Laukkanen, M ; Saltevo, J ; Tiihonen, M ; Forsen, M ; Granlund, H ; Jonsson, Ac ; Nyroos, B ; Kinnunen, P ; Orvola, A ; Salonen, T ; Vähänen, A ; Paldanius, Kr ; Riihelä, M ; Ryysy, L ; Laukkanen, Kh ; Nyländen, P ; Sademies, A ; Anderson, S ; Asplund, B ; Byskata, U ; Liedes, P ; Kuusela, M ; Virkkala, T ; Nikkola, A ; Ritola, E ; Niska, Tm ; Saarinen, H ; Oukko-Ruponen, Se ; Virtanen, T ; Lyytinen, Va ; Kari, Ph ; Simonen, T ; Kaprio, Sa ; Kärkkäinen, J ; Rantaeskola, B ; Kääriäinen, Tp ; Haaga, J ; Pietiläinen, Al ; Klemetti, S ; Nyandoto, T ; Rontu, E ; Satuli-Autere, S ; Toivonen, Kr ; Lansimaki, Hv ; Ahonen, R ; Ivaska-Suomela, M ; Jauhiainen, A ; Laine, Mm ; Pellonpää, T ; Puranen, R ; Airas, Ma ; Laakso, J ; Rautavaara, K ; Erola, Rm ; Jatkola, E ; Lönnblad, Tr ; Malm, A ; Mäkelä, J ; Rautamo, E ; Hentunen, P ; Lagerstam, J ; Feodoroff, M ; Gordin, D ; Heikkilä, O ; Hietala, K ; Fagerudd, J ; Korolainen, M ; Kyllönen, L ; Kytö, J ; Lindh, S ; Pettersson-Fernholm, K ; Rosengård-Bärlund, M ; Sandelin, A ; Thorn, L ; Tuomikangas, J ; Vesisenaho, T ; Wadén, J ; Sipilä, V ; Kalliomäki, Ft ; Koskelainen, J ; Nikkanen, R ; Savolainen, N ; Sulonen, H ; Valtonen, E ; Norvio, L ; Hämäläinen, A ; Toivanen, E ; Parta, Ja ; Pirttiniemi, I ; Aranko, S ; Ervasti, S ; Kauppinen-Mäkelin, R ; Kuusisto, A ; Leppälä, T ; Nikkilä, K ; Pekkonen, L ; Jokelainen, Ks ; Kananen, K ; Karjalainen, M ; Kemppainen, P ; Mankinen, Am ; Reponen, A ; Sankari, M ; Suominen, P ; Lappalainen, A ; Liimatainen, M ; Santaholma, J ; Aimolahti, A ; Huovinen, E ; Ilkka, V ; Lehtimäki, M ; Pälikkö-Kontinen, E ; Vanhanen, A ; Koskinen, E ; Siitonen, T ; Huttunen, E ; Ikäheimo, R ; Karhapää, P ; Kekäläinen, P ; Laakso, M ; Lakka, T ; Lampainen, E ; Moilanen, L ; Tanskanen, S ; Niskanen, L ; Tuovinen, U ; Vauhkonen, I ; Voutilainen, E ; Rcw, Ma ; Chan, Jcn ; Huang, Y ; Lan, Hy ; Lok, S ; Tomlinson, B ; Tsui, Skw ; Yu, W ; Yip, Kyl ; Chan, Tf ; Fan, X ; So, Wy ; Szeto, Cc ; Tang, N ; Luk, Ao ; Tian, X ; Jiang, G ; Tam, Cht ; Lee, Hm ; Lim, Ckp ; Chan, Kkh ; Xie, F ; Acw, Ng ; Cheung, Gpy ; Yeung, Mw ; Mai, S ; Zhang, S ; Yu, P ; Weng, M ; Maxwell, Ap ; Mcknight, Aj ; Savage, Da ; Walker, J ; Thomas, S ; Viberti, Gc ; Boulton, Ajm ; Marshall, S ; Demaine, Ag ; Millward, Ba ; Bain, Sc ; Sandholm, N ; Forsblom, C ; Harjutsalo, V ; Mäkinen, Vp ; Ahola, Aj ; Dahlström, E ; Lehto, M ; Lithovius, R ; Panduru, Nm ; Parkkonen, M ; Saraheimo, M ; Söderlund, J ; Soro-Paavonen, A ; Syreeni, A ; Thorn, Lm ; Tolonen, N ; Groop, Ph ; Mckay, Gj ; Salem, Rm ; Isakova, T ; Palmer, C ; Guiducci, C ; Taylor, A ; Mirel, Db ; Williams, Ww ; Hirschhorn, Jn ; Florez, Jc ; Brennan, Ep ; Sadlier, Dm ; Martin, F ; Godson, C ; Mayer, L ; Gubitosi-Klug, R ; Bourne, P ; Schutta, M ; Lackaye, Me ; Gregory, Ns ; Kruger, D ; Jones, Jk ; Bhan, A ; Golden, E ; Aiello, L ; Larkin, M ; Nathan, D ; Ziegler, G ; Caulder, S ; Pittman, C ; Luttrell, L ; Lopes-Virella, M ; Johnson, M ; Gunyou, K ; Bergenstal, R ; Vittetoe, B ; Sivitz, W ; Flaherty, N ; Bantle, J ; Hitt, S ; Goldstein, D ; Hainsworth, D ; Cimino, L ; Orchard, T ; Wigley, C ; Dagogo-Jack, S ; Strowig, S ; Raskin, P ; Barnie, A ; Zinman, B ; Fahlstrom, R ; Palmer, J ; Harth, J ; Driscoll, M ; Mcdonald, C ; Lipps Hagan, J ; May, M ; Levandoski, L ; White, N ; Gatcomb, P ; Tamborlane, W ; Adelman, D ; Colson, S ; Molitch, M ; Lorenzi, G ; Mudaliar, S ; Johnsonbaugh, S ; Miller, R ; Canady, J ; Schade, D ; Bernal, Ml ; Malone, J ; Morrison, A ; Martin, C ; Herman, W ; Pop-Busui, R ; Cowie, C ; Leschek, E ; Cleary, P ; Lachin, J ; Braffett, B ; Steffes, M ; Arends, V ; Blodi, B ; Danis, R ; Lawrence, D ; Wabers, H ; Soliman, E ; Zhang, Zm ; Campbell, C ; Hensley, S ; Keasler, L ; Mark, M ; Albertini, M ; Boustany, C ; Ehlgen, A ; Gerl, M ; Huber, J ; Schölch, C ; Zimdahl-Gelling, H ; Groop, L ; Agardh, E ; Ahlqvist, E ; Ajanki, T ; Al Maghrabi, N ; Almgren, P ; Apelqvist, J ; Bengtsson, E ; Berglund, L ; Björckbacka, H ; Blom-Nilsson, U ; Borell, M ; Burström, A ; Cilio, C ; Cinthio, M ; Dreja, K ; Dunér, P ; Engelbertsen, D ; Fadista, J ; Gomez, M ; Goncalves, I ; Hedblad, B ; Hultgårdh, A ; Johansson, Me ; Kennbäck, C ; Kravic, J ; Ladenvall, C ; Lernmark, Å ; Lindholm, E ; Ling, C ; Luthman, H ; Melander, O ; Neptin, M ; Nilsson, J ; Nilsson, P ; Nilsson, T ; Nordin, G ; Orho-Melander, M ; Ottoson-Laakso, E ; Persson, A ; Persson, M ; Persson, Må ; Postma, J ; Pranter, E ; Rattik, S ; Sterner, G ; Tindberg, L ; Wigren, M ; Zetterqvist, A ; Åkerlund, M ; Ostling, G ; Kanninen, T ; Ahonen-Bishopp, A ; Eliasson, A ; Herrala, T ; Tikka-Kleemola, P ; Hamsten, A ; Betsholtz, C ; Björkholm, A ; Foroogh, F ; Genové, G ; Gertow, K ; Gigante, B ; He, B ; Leander, K ; Mcleod, O ; Nastase-Mannila, M ; Patrakka, J ; Silveira, A ; Strawbridge, R ; Tryggvason, K ; Vikström, M ; Ohrvik, J ; Österholm, Am ; Thorand, B ; Gieger, C ; Grallert, H ; Ludwig, T ; Nitz, B ; Schneider, A ; Wang-Sattler, R ; Zierer, A ; Remuzzi, G ; Benigni, A ; Donadelli, R ; Lesti, Md ; Noris, M ; Perico, N ; Perna, A ; Piras, R ; Ruggenenti, P ; Rurali, E ; Dunger, D ; Chassin, L ; Dalton, N ; Deanfield, J ; Horsford, J ; Rice, C ; Rudd, J ; Walker, N ; Whitehead, K ; Wong, M ; Colhoun, H ; Adams, F ; Akbar, T ; Belch, J ; Deshmukh, H ; Dove, F ; Ellingford, A ; Farran, B ; Ferguson, M ; Henderson, G ; Houston, G ; Khan, F ; Leese, G ; Liu, Y ; Livingstone, S ; Looker, H ; Mccann, M ; Mcgurnaghan, S ; Morris, A ; Newton, D ; Pearson, E ; Reekie, G ; Smith, N ; Shore, A ; Aizawa, K ; Ball, C ; Bellenger, N ; Casanova, F ; Frayling, T ; Gates, P ; Gooding, K ; Hattersley, A ; Ling, R ; Mawson, D ; Shandas, R ; Strain, D ; Thorn, C ; Smith, U ; Hammarstedt, A ; Häring, H ; Pedersen, O ; Sesti, G ; Fagerholm, E ; Toppila, I ; Valo, E ; Salomaa, V ; Havulinna, A ; Kristiansson, K ; Okamo, P ; Peltola, T ; Perola, M ; Pietilä, A ; Ripatti, S ; Taimi, M ; Ylä-Herttuala, S ; Babu, M ; Dijkstra, M ; Gurzeler, E ; Huusko, J ; Kholová, I ; Merentie, M ; Poikolainen, M ; Mccarthy, M ; Groves, C ; Juliusdottir, T ; Karpe, F ; Lagou, V ; Rayner, W ; Robertson, N ; van Zuydam, N ; Cobelli, C ; Di Camillo, B ; Finotello, F ; Sambo, F ; Toffolo, G ; Trifoglio, E ; Bellazzi, R ; Barbarini, N ; Bucalo, M ; Larizza, C ; Magni, P ; Malovini, A ; Marini, S ; Mulas, F ; Quaglini, S ; Sacchi, L ; Vitali, F ; Ferrannini, E ; Boldrini, B ; Kozakova, M ; Mari, A ; Morizzo, C ; Mota, L ; Natali, A ; Palombo, C ; Venturi, E ; Walker, M ; Patrono, C ; Pagliaccia, F ; Rocca, B ; Nuutila, P ; Haukkala, J ; Knuuti, J ; Roivainen, A ; Saraste, A ; Mckeague, P ; Colombo, M ; Steckel-Hamann, B ; Bokvist, K ; Shankar, S ; Thomas, M ; Gan, Lm ; Heinonen, S ; Jönsson-Rylander, Ac ; Momo, R ; Schnecke, V ; Unwin, R ; Walentinsson, A ; Whatling, C ; Nogoceke, E ; Pacheco, Gd ; Formentini, I ; Schindler, T ; Tortoli, P ; Bassi, L ; Boni, E ; Dallai, A ; Guidi, F ; Lenge, M ; Matera, R ; Ramalli, A ; Ricci, S ; Viti, J ; Jablonka, B ; Crowther, D ; Gassenhuber, J ; Hess, S ; Hubschle, T ; Juretschke, Hp ; Rutten, H ; Sadowski, T ; Wohlfart, P ; Brosnan, J ; Clerin, V ; Fauman, E ; Hyde, C ; Malarstig, A ; Pullen, N ; Tilley, M ; Tuthill, T ; Vangjeli, C ; Linda T, Ziemek D. ; Ahluwalia, Tarunveer S ; Almgren, Peter ; Schulz, Christina-Alexandra ; Orho-Melander, Marju ; Linneberg, Allan ; Christensen, Cramer ; Witte, Daniel R ; Grarup, Niels ; Brandslund, Ivan ; Melander, Olle ; Paterson, Andrew D ; Tregouet, David ; Maxwell, Alexander P ; Lim, Su Chi ; Ronald C W, Ma ; Tai, E Shyong ; Maeda, Shiro ; Lyssenko, Valeriya ; Tuomi, Tiinamaija ; Krolewski, Andrzej S ; Rich, Stephen S ; Hirschhorn, Joel N ; Florez, Jose C ; Dunger, David ; Pedersen, Oluf ; Hansen, Torben ; Rossing, Peter ; Remuzzi, Giuseppe ; Brosnan, Mary Julia ; Palmer, Colin N A ; Groop, Per-Henrik ; Colhoun, Helen M ; Groop, Leif C ; Mccarthy ; Mark, I ; Palombo, Carlo ; Clinicum ; Diabetes and Obesity Research Program ; Research Programs Unit ; yksikkö, Nefrologian ; Department of Medicine ; Institute for Molecular Medicine Finland ; Tiinamaija Tuomi Research Group ; yksikkö, Endokrinologian ; Per Henrik Groop / Principal Investigator ; Leif Groop Research Group ; HUS Abdominal Center ; HUS Internal Medicine and Rehabilitation ; Lee Kong Chian School of Medicine (LKCMedicine) |
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| Quelle: | Scopus-Elsevier Finnish Diabetic Nephropathy Study (FinnDiane), Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Research Group (Daniel Witte; member), Ahluwalia, T S, Linneberg, A, Christensen, C & Brandslund, I 2018, ' A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes ', Diabetes, vol. 67, no. 7, pp. 1414-1427 https://doi.org/10.2337/db17-0914 Diabetes 67, 1414-1427 (2018) Diabetes van Zuydam, N R, Ahlqvist, E, Sandholm, N, Deshmukh, H, Rayner, N W, Abdalla, M, Ladenvall, C, Ziemek, D, Fauman, E, Robertson, N R, McKeigue, P M, Valo, E, Forsblom, C, Harjutsalo, V, Perna, A, Rurali, E, Marcovecchio, M L, Igo, R P, Salem, R M, Perico, N, Lajer, M, Käräjämäki, A, Imamura, M, Kubo, M, Takahashi, A, Sim, X, Liu, J, van Dam, R M, Jiang, G, Tam, C H T, Luk, A O Y, Lee, H M, Lim, C K P, Szeto, C C, So, W Y, Chan, J C N, Ang, S F, Dorajoo, R, Wang, L, Hua Clara, T S, McKnight, A-J, Duffy, S, Pezzolesi, M G, Consortium, G, Marre, M, Gyorgy, B, Hadjadj, S, Hiraki, L T, Ahluwalia, T S, Maxwell, A P & FINNDIANE Study centres 2018, ' A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes ', Diabetes, vol. 67, no. 7, pp. 1414-1427 . https://doi.org/10.2337/db17-0914 van Zuydam, N R, Ahlqvist, E, Sandholm, N, Deshmukh, H, Rayner, N W, Abdalla, M, Ladenvall, C, Ziemek, D, Fauman, E, Robertson, N R, McKeigue, P M, Valo, E, Forsblom, C, Harjutsalo, V, Perna, A, Rurali, E, Marcovecchio, M L, Igo, R P, Salem, R M, Perico, N, Lajer, M, Käräjämäki, A, Imamura, M, Kubo, M, Takahashi, A, Sim, X, Liu, J, van Dam, R M, Jiang, G, Tam, C H T, Luk, A O Y, Lee, H M, Lim, C K P, Szeto, C C, So, W Y, Chan, J C N, Ang, S F, Dorajoo, R, Wang, L, Hua Clara, T S, McKnight, A-J, Duffy, S, Pezzolesi, M G, Consortium, G, Marre, M, Gyorgy, B, Hadjadj, S, Hiraki, L T & Ahluwalia, T S & Colhoun, H M 2018, ' A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes ', Diabetes . https://doi.org/10.2337/db17-0914 Finnish Diabetic Nephropathy Study (FinnDiane) 2018, ' A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes ', Diabetes, vol. 67, no. 7, pp. 1414-1427 . https://doi.org/10.2337/db17-0914; S. 1414-1427 |
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