Correlates of Protection Against SARS-CoV-2 in Rhesus Macaques
In: Nature, Jg. 590 (2020-12-01), Heft 7847, S. 630-634
Online
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Zugriff:
Recent studies have reported the protective efficacy of both natural1 and vaccine-induced2–7 immunity against challenge with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in rhesus macaques. However, the importance of humoral and cellular immunity for protection against infection with SARS-CoV-2 remains to be determined. Here we show that the adoptive transfer of purified IgG from convalescent rhesus macaques (Macaca mulatta) protects naive recipient macaques against challenge with SARS-CoV-2 in a dose-dependent fashion. Depletion of CD8+ T cells in convalescent macaques partially abrogated the protective efficacy of natural immunity against rechallenge with SARS-CoV-2, which suggests a role for cellular immunity in the context of waning or subprotective antibody titres. These data demonstrate that relatively low antibody titres are sufficient for protection against SARS-CoV-2 in rhesus macaques, and that cellular immune responses may contribute to protection if antibody responses are suboptimal. We also show that higher antibody titres are required for treatment of SARS-CoV-2 infection in macaques. These findings have implications for the development of SARS-CoV-2 vaccines and immune-based therapeutic agents. Adoptive transfer of purified IgG from convalescent macaques protects naive macaques against SARS-CoV-2 infection, and cellular immune responses contribute to protection against rechallenge with SARS-CoV-2.
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Correlates of Protection Against SARS-CoV-2 in Rhesus Macaques
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Autor/in / Beteiligte Person: | Tostanoski, Lisa H. ; Alex Van Ry ; Alex Lee Zhu ; Teow, Elyse ; Chandrashekar, Abishek ; Patel, Shivani A. ; Liu, Jinyan ; Peter, Lauren ; Cook, Anthony L. ; Yalley-Ogunro, Jake ; Alter, Galit ; Barouch, Dan H. ; Lewis, Mark G. ; Loos, Carolin ; Dagotto, Gabriel ; Yu, Jingyou ; Gebre, Makda S. ; Cabus, Mehtap ; Nampanya, Felix ; Li, Zhenfeng ; Brown, Renita ; Lauffenburger, Douglas A. ; Jacob-Dolan, Catherine ; Bondzie, Esther A. ; Blade, Kelvin ; Pessaint, Laurent ; Mercado, Noe B. ; Andersen, Hanne ; McMahan, Katherine ; Atyeo, Caroline |
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Zeitschrift: | Nature, Jg. 590 (2020-12-01), Heft 7847, S. 630-634 |
Veröffentlichung: | 2020 |
Medientyp: | unknown |
ISSN: | 1476-4687 (print) ; 0028-0836 (print) |
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