Dissociating polysensitization and multimorbidity in children and adults from a Polish general population cohort
In: Clinical and Translational Allergy Clinical and Translational Allergy, 2019, Jg. 9 (2019), Heft 1, S. 1-10
Online
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Zugriff:
International audience; Background: Links between multimorbidity of allergic diseases and allergen sensitization are still under debate, especially in adults. This study aimed to establish a relationship between polysensitization and allergic multimorbidity in children and adults and the allergens involved in multimorbidity.Material and method: A cross-sectional multicentre study enrolled children aged 6-7 and 13-14 years and adults aged 20-44 years from a Polish national cohort. The diagnosis of allergic diseases was made by a physician. Skin prick tests to 13 allergens and serum IgE levels to 4 allergens were tested.Results: Among the 3856 participants, single disease (asthma, allergic rhinitis or atopic dermatitis) was diagnosed in 27.7% subjects and allergic multimorbidity in 9.3%. Allergic multimorbidity occurred more commonly in children than in adults (p < 0.01). Asthma or atopic dermatitis alone were not associated with polysensitization. Rhinitis and multimorbidity were associated with polysensitization. Allergic multimorbidity occurred in 2.2% of participants with negative skin prick tests, 9.8% of those with one positive prick test (SPT ≥ 3 mm) and 20.6% of polysensitized ones (p < 0.001). There was an increasing risk of multimorbidity depending on the number of positive prick tests for both SPT ≥ 3 mm (OR 9.6-16.5) and SPT ≥ 6 mm (OR 5.9-13.7). A statistically significant relationship was found between allergic multimorbidity and sensitization to cat and mite allergens.Conclusions: Multimorbidity is associated with polysensitization especially in children compared with adults in Polish population cohort. New insights into single disease patterns were found: bronchial asthma is the strongest risk factor for the development of multimorbidity in comparison with allergic rhinitis and atopic dermatitis.
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Dissociating polysensitization and multimorbidity in children and adults from a Polish general population cohort
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Autor/in / Beteiligte Person: | Białoszewski, Artur Z. ; Tomaszewska, Aneta ; Bousqet, Jean ; Szylling, Anna ; Raciborski, Filip ; Namysłowski, Andrzej ; Lipiec, Agnieszka ; Wojas, Oksana ; Samel-Kowalik, Piotr ; Grąbczewska, Aleksandra ; Samoliński, Krzysztof ; Samoliński, Bolesław ; Krzych-Fałta, Edyta ; Piekarska, Barbara ; Zieliński, Wojciech ; Sybilski, Adam J. ; Walkiewicz, Artur ; Medical University of Warsaw - Poland ; Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR) ; Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA) ; Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO) ; Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA) ; Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM) ; European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA) ; Charité Campus Virchow-Klinikum (CVK) ; Warsaw University of Life Sciences (SGGW) ; Salvy-Córdoba, Nathalie ; Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA) ; Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ) |
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Zeitschrift: | Clinical and Translational Allergy Clinical and Translational Allergy, 2019, Jg. 9 (2019), Heft 1, S. 1-10 |
Veröffentlichung: | Wiley, 2019 |
Medientyp: | unknown |
ISSN: | 2045-7022 (print) |
DOI: | 10.1186/s13601-019-0246-y |
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